ID I1BWR8_RHIO9 Unreviewed; 1578 AA.
AC I1BWR8;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN ORFNames=RO3G_05353 {ECO:0000313|EMBL:EIE80648.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE80648.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE80648.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; CH476734; EIE80648.1; -; Genomic_DNA.
DR STRING; 246409.I1BWR8; -.
DR VEuPathDB; FungiDB:RO3G_05353; -.
DR eggNOG; KOG0017; Eukaryota.
DR InParanoid; I1BWR8; -.
DR OMA; ECKSAFE; -.
DR OrthoDB; 1368576at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00024; CD_CSD; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 1174..1332
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1467..1525
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1036..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1534..1578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1055
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1534..1570
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1578 AA; 180990 MW; 041BB700DE9CF0CA CRC64;
MEQDPSDMEI EQASQDPSLS GDGSEVIPKI NANAHEITSD HDDIDAEVSK LLRYKKEESA
RLYQKHIMAG EEEQADLAFN KMRKYGAQLL ALSGKLVPLT STPVKKEIGL RLTQNDIPKF
QLTSWPDIPF PGEKCYESVE HFLRSFEKVI YSAALDIQEV WRRYLPVSLA FDHDDWVEKD
LKRCDTWTSA RIVFTNKFLT DNARTDAMHR LFTMTMNKHE SISSYMTRFL STCIEAGANK
NDPMVAARFK ASFSEPVLEK CKTAFVLKEN KNVPWTVERA AEIARNLLGD DPRTYTSSSY
ANIASGSKRI HTNAGPFSIP KRNKGHGSSG AFFCSRHGGS NANHNEDDCF SKTNKKNDAA
STVKNKYYGN KNFPQKASTS KPCRYCGRSW SHGHQCQEYA DFKRKLHVDP KKPRDSDKSI
YAIVRTTNDE NDDDHDMTEA ENHAYDLNSV NGSLNFLSSD NNCKRIGQTD PLTLTYMNNI
SFKHSFEVVN FNETMTQEFD VLLGTDVLGK MNIGLTGVAY KYPGNEDDYS NRLKEDAQFL
NMNFDANNEI EPNNSPYGTE DQQKQFIAYI QNAIDDNQNI PAGSFCTVPE SVVELPMEKG
AKSFKRQYPI AHRQMPELEE QINEWLKAGI IKENRANTSF NSPLLMVPKK DENNEITSHR
VCLDVRGINK LIPDVVYPVP KIRSIFDNLA GGEVFTKIDL KNAYNSFLVA PKDQHKLSFQ
FKNRTYTFQG CCFGLKTVTA IFCKVMKILF ADMDFIETYV DDCVIKGTAD NHASNVKKVI
ERLTSVNLKI NVKKCSWYQR SIYLLGFVVE SGGIIKVDPR RLTNIDSWPI PRNKKEVMRL
MGIVSYMRDF IPLISRVAAP IDRLRNDPDV QNNWTQEHTD AFIALKEILK SKTLLHTPDL
SKKFYVATDA SQYGVGAVLT QRDELNRTLH IAFASKSLSP SQRKWNTTKR ELYAVVFALE
KYREFLWGNK FELRTDHKAL MYLHTQEQAN PMMIGWLETL LDFNFDVIHI QGILNQLPDL
LSRLYEPCLN NEFMLGGGDA SQKENKKEKK EIKNKNQNKI KVKRQTNSTA KRHNLIYSQD
KKLNVLAVKI KNKKFANNPT TDYMTPPPEK RARLLEDAHT FGHFGSTSIV EQLHSQGLHW
NNIYKDATET IKSCIECQRH NISKKGYHPL KNILAYLPFD HIGIDLLGPL PVTANENVYV
LVMIDVCTRY IILRPLKNKQ SDTVAKELIK IFGDYGIPKI IQSDNGREFK NSLMHSLSKH
LGIDRRYSTA FHSRGNGVSE SAVKTTLNTI RKMVNSNSND WDDVLPIVQL ASNYKIRHRS
KSAPFSLMFA RRLNSFEDYG DQSIADKIPN RPVTEQELIE RTDRMYQIVF PAIRERTQKI
IEEASKRFND KNMIIDLPKD TAVMVRLPGR TSKLSPLYEG PYIVVRKTQG GSYVLKDEQN
ELLHREYVPS ELKIVSIDET AIEDTYYEVE DIRDHRGGPG QREYLVKWAG YGERENTWEK
ASSFSSTVPI DKYWLKRKEL KELEQARKQK MIANEKDYTK KTSARPNVTE ENKNHKRKDM
VQDSTVLRKS KRIRNNRN
//
