ID   I1C414_RHIO9            Unreviewed;       530 AA.
AC   I1C414;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Vacuolar protein 8 {ECO:0000256|ARBA:ARBA00026209};
GN   ORFNames=RO3G_07899 {ECO:0000313|EMBL:EIE83194.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE83194.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE83194.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC       anchor {ECO:0000256|ARBA:ARBA00004635}. Vacuole membrane
CC       {ECO:0000256|ARBA:ARBA00004592}; Lipid-anchor
CC       {ECO:0000256|ARBA:ARBA00004592}.
CC   -!- SIMILARITY: Belongs to the beta-catenin family.
CC       {ECO:0000256|ARBA:ARBA00005462}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476736; EIE83194.1; -; Genomic_DNA.
DR   AlphaFoldDB; I1C414; -.
DR   STRING; 246409.I1C414; -.
DR   VEuPathDB; FungiDB:RO3G_07899; -.
DR   eggNOG; KOG4224; Eukaryota.
DR   InParanoid; I1C414; -.
DR   OMA; LEIVQCR; -.
DR   OrthoDB; 2721872at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043495; F:protein-membrane adaptor activity; IEA:InterPro.
DR   GO; GO:0071562; P:nucleus-vacuole junction assembly; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR045156; Vac8.
DR   PANTHER; PTHR47249; VACUOLAR PROTEIN 8; 1.
DR   PANTHER; PTHR47249:SF1; VACUOLAR PROTEIN 8; 1.
DR   Pfam; PF00514; Arm; 3.
DR   SMART; SM00185; ARM; 7.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 5.
PE   3: Inferred from homology;
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW   Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT   REPEAT          91..133
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          132..162
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          223..265
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          264..306
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          305..348
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ   SEQUENCE   530 AA;  58701 MW;  4AF3DB0988CC890A CRC64;
     MGNSCSSCCS SCCGKKNKNG LYEPLLQENE REAIAELLQY LENRGDTNFF EGQPLQALSI
     LAYSDNVDLQ RSAALAFAEI TEKDVRQVDR DTLNPILFLL QSHDVEVQRA ASAALGNLAV
     NTENKLLIVK LGGLEQLVRQ MGSPNVEVQC NAVGCITNLA THAFGRLGKI KRSKGAKECH
     WRFIKYDAYT SPDADVQYYC TTALSNIAVD ASNRKKLAQT DSRLVQYLIA LMDTKSLKVQ
     CQAALALRNL ASDEKYQLEI VRCKGLAPLL RLLKSSFLPL ILSSVACIRN ISIHPANESP
     IIDGGFVNPL IELLAYDDNE EIQCHAISTL RNLAASSERN KRAIVEAGAI ERIKALINKV
     PQSVQTEMTA AIAVLALSDE LKQRLLSMDV LDVLIELTSH TNLEVEGNSA AAIGNLSSKV
     PDYTPFVNAW KSPFGGLEKF LIRFLSEDQD VAFQHIGIWT IEQFIDGGDE RLLQLIVSSH
     SVLESVERIM NKTQVSSNVE DMDDNIHVLA KRVHYNLQEI SLKDFNHKKD
//