ID I1C6I1_RHIO9 Unreviewed; 815 AA.
AC I1C6I1;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=SET domain-containing protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=RO3G_08766 {ECO:0000313|EMBL:EIE84061.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE84061.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE84061.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR EMBL; CH476737; EIE84061.1; -; Genomic_DNA.
DR AlphaFoldDB; I1C6I1; -.
DR STRING; 246409.I1C6I1; -.
DR VEuPathDB; FungiDB:RO3G_08766; -.
DR eggNOG; KOG4442; Eukaryota.
DR InParanoid; I1C6I1; -.
DR OMA; RYLYSEM; -.
DR OrthoDB; 950362at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR Gene3D; 1.10.1740.100; Set2, Rpb1 interacting domain; 1.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR042294; SETD2_animal.
DR InterPro; IPR013257; SRI.
DR InterPro; IPR038190; SRI_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR46711; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR PANTHER; PTHR46711:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF08236; SRI; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 70..156
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 163..179
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 480..513
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 190..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..219
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 92788 MW; D9F4D1B0CFECE800 CRC64;
MHRSSVDSEN GDANFNSRFS EHANEQELQL EAKTQLPSAT ADAMETYVNI SENIYCGSAT
GKSIAEESMP CEYVIRTEKK GFGLRALTDL PTNAFIMEYI GEIIDATKKG CLARFINHSC
NPNCVTQKWV VGKNMRIGIF TTRCIKAGEE LTFDYKFERY GAQAQVCYCG EQVCKGFIGG
SFKNNSKIND ESFDNEKLDS NRDEEEDDDD EDERKQSDSN EDEEEAVTLT QKRMLRKMNR
RKSHQPLKNP DEMKSFVKRM LDSVVRVFHV LSQLPLANRN GLEDCKMFDI VEKFVNDENE
EVGKLAEQLL KNWEQLKSVY RIPKRNVVET PQPSNGHTNK DGANGTDMSK DSQSSCQYDS
SREFFDPDDD YYEYFPMDVN ANEIKWRIEY PPRCVIPTAP RAMMDAKNGY LGYTRHIRTP
KPSSSYLAHV STGYNPDDVH PFHSSSFHNR IKSSDSSVLM NDTQSIDSAS AVSVTTGPLR
KLPSNWKFAY AEDGTIYYYH RYTGKTQWNF PEEKSSSIEG VNQSDLEDLV EKTIQDAEKK
KVVESIRSDS PAALIASRLS TDSSQAATTL ASRRGSDEVD GALNEAQLKK GIGKIVTKYL
SSKQKGLWKD DKHLFKELAR KITHHIVDRE IQSSRKIQTM NSYVRTKVEK FIDAHGVDLV
NKIVRKRKHP STAPKEVQVD SPRSIVSEDT SKYSKVIFSP SVSPPNNTVV SLPENGTEWH
YENLHSPPVK KRALVKNDTI YTSNQSMKST ADLTVMYHQI QPLHITEAVV DTILQESPHH
QPITTDILQT HPKEDHYPMM TWIDEDEISY SYFYL
//
