ID I1C8D4_RHIO9 Unreviewed; 1036 AA.
AC I1C8D4;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
GN ORFNames=RO3G_09424 {ECO:0000313|EMBL:EIE84714.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE84714.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE84714.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-
CC tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA-
CC COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001372};
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DR EMBL; CH476738; EIE84714.1; -; Genomic_DNA.
DR AlphaFoldDB; I1C8D4; -.
DR STRING; 246409.I1C8D4; -.
DR VEuPathDB; FungiDB:RO3G_09424; -.
DR eggNOG; KOG0437; Eukaryota.
DR InParanoid; I1C8D4; -.
DR OMA; KFIEWQF; -.
DR OrthoDB; 5472610at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR004493; Leu-tRNA-synth_Ia_arc/euk.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00395; leuS_arch; 1.
DR PANTHER; PTHR45794:SF1; LEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR45794; LEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00133; tRNA-synt_1; 2.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000009138}.
FT DOMAIN 46..115
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 188..754
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
SQ SEQUENCE 1036 AA; 117755 MW; 052577BEA75C8C48 CRC64;
MSTEAPKTAK RDALREFEGK ARALWDNEKA FEINAPTIEE HPNYEDLHKT HPKYMACMPY
PYMNGRLHLG HAFTFSKVEF CIGYERMKGR RALLPQGFHC TGMPIKACAD KLAREIEMFG
KNFEKYDEAK EAEKKTEVNK NVKSKVAAKT GNVTYQFQIM LSLGIPITEI HKFSDPYYWT
EFFPPQTISD MNAFGAKVDW RRAFITTDAN PYYDSFVRWQ MRKLREMQKI KFGERYTIYS
IIDKQPCMDH DRASGEGVGP QEYTGIKMEV LEWSDAAKEA LVASNDNLKG KKIYLVAATL
RPETMYGQTN CFVGTDIKYG VYKVNENEAF VVTERAARNM AYQKIFAKEG SIEKLAEIDG
KSIVGTKIHA PLSQYSAVYV LPMDNVLSTK GTGVVTSVPS DSPDDYATLC DLKKKPDYYN
IKAEWVAFDP VPLIETPSYG NLTAPKLCEI KKINSQKDRV QLAEAKELAY KEAFYQGVMC
IGEFSGMAVQ EAKNKVKDIL INSKEAFVYN EPEGLVMSRS GDECVVALLD QWYIDYGEEE
WKAKTKKCLS QMNTYTVETR HQFEQVLDWL NKWACARSFG LGTKLPWDEQ FLVESLSDST
IYMAYYTVAH LLHNDLKGSS VGSAGITAEQ MTDSVWNYIF RLGEYPVDCG VPQATLDRLR
REYEYFYPLD LRASGKDLVP NHLTFFLYNH TAIFPEDKWP QGVRSNGHLL LDSKKMSKST
GNFMTMSDAV IKYGADATRF ALADAGDSVE DANFEDATAN AAILRLYTLL EWSEEQVAKA
DTLRTGEFTF FDKIFVNEMN KLINLTEAAY DATCYREVLK YGVYEFQAAK DAYQVACTEA
VLKKEGLVVS APFPKPSAPV DESLEAATRY IRRTTKAIRD AELNLIKKKK KGKAAESEYK
PSEPKSLKIF VATKFPEWQE ASLNVMKVHY NNGEFDDVKI RQELGAQGML KDKKVMPFIQ
EQKKLIAKEG PVAFNRTLIF NEVETLEKAV DELKRALGFH TISIFGHDQW PEEYIKTAES
AVPGVPSFSF KNESKE
//