ID I1CBR2_RHIO9 Unreviewed; 743 AA.
AC I1CBR2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=RO3G_10602 {ECO:0000313|EMBL:EIE85892.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE85892.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE85892.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; CH476739; EIE85892.1; -; Genomic_DNA.
DR AlphaFoldDB; I1CBR2; -.
DR STRING; 246409.I1CBR2; -.
DR VEuPathDB; FungiDB:RO3G_10602; -.
DR eggNOG; KOG1703; Eukaryota.
DR eggNOG; KOG2710; Eukaryota.
DR InParanoid; I1CBR2; -.
DR OMA; WQMQSSV; -.
DR OrthoDB; 1329523at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45808; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR PANTHER; PTHR45808:SF2; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009138}.
FT DOMAIN 177..207
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 446..632
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 674..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 84274 MW; 90EF9655FAC877C3 CRC64;
MTSEELKEAQ NIMEEKVYRI WTVLSAFEES AAGCISDMLL HVSEGSYAEG VKMADYFVTH
VEVLFSAIDD LVDEHLKQTK QELQYDRESS MLCKKVSNFF SLLSHTQENG LRKIGITQDL
LSLVTGLAHY LKVLIRIGLT GALRLEKKGD TKSTAISRFL SQLMELANKK RQHLHEADYT
VSSDLCQFCR KQCEDVCFSK CIQHTDSYAR GVQYVSKLRQ SSFLLRVALR RLYSLLNVPD
PMVAYYGQPT TDQTHLQQQL QQKVIQPQAQ QQTQHYVPPM PPLPKLANSE DLPNEEIHLN
DIKRMKSTQM NRKVTNSHRI GKRSTLMETP LPNAAFVSSQ SDDKTNRPQS TVSNKRASFN
ELGSFTESST RHRYTKSVPE AKSFYFAELG TLQHFMLKHI AVLYLEEILH DHFTLEELAD
LIDDKKNSTL WDVLVEKNGI ESNLGVGPTR IIKIPSFIDE SISSMKQMDM SVEGIFRRNG
NIRKLKELSD EIDRNPSSVQ LNQESPIQIA ALIKKFLREL PDPLLTFKLH KLFITAQKLE
SEAERKRVTH LACCLLPKAN RDTMEVLFVF MKWVSQFAHL ENNTGNKMGI VNLATVIAPN
ILYSKSKDPV KDESFYSIET VTMLLQNAEE FATVPEDFIP LLQNLSYEEA DMDMNVRHIL
KKCEMVMKLK RSKAAGGPIP PQLPRQHSSP AAVFSNSSTP ESESPCSPDQ LSSSPQSVSN
MENHLKLLNA QVPVLRSQSS SQS
//
