ID   I1CFA7_RHIO9            Unreviewed;       593 AA.
AC   I1CFA7;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Carotenoid oxygenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=RO3G_11848 {ECO:0000313|EMBL:EIE87137.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE87137.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE87137.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC   -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC       {ECO:0000256|ARBA:ARBA00006787}.
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DR   EMBL; CH476740; EIE87137.1; -; Genomic_DNA.
DR   AlphaFoldDB; I1CFA7; -.
DR   STRING; 246409.I1CFA7; -.
DR   VEuPathDB; FungiDB:RO3G_11848; -.
DR   eggNOG; KOG1285; Eukaryota.
DR   InParanoid; I1CFA7; -.
DR   OMA; CKNFFAR; -.
DR   OrthoDB; 294919at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   InterPro; IPR004294; Carotenoid_Oase.
DR   PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR   PANTHER; PTHR10543:SF24; CAROTENOID ISOMEROOXYGENASE; 1.
DR   Pfam; PF03055; RPE65; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR604294-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138}.
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         584
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ   SEQUENCE   593 AA;  66562 MW;  4890E6C4BFD33B56 CRC64;
     MSDIEDTNPS LQIQSEPDYP LQPIVAKDDT SIVDNRSLLN DQGQPNLSRT PSATVPDEST
     KEDASHTKGF CNTTDSKQVV DLEVDGQLPD WLASEHYTIG PGTYDVKYTR KIEIDGILQS
     ATATFTLGHW FDADHHGYAP NFPAGLFKTH PNQTMLIKFL NNGKKPKPDR VPCNQRIMTQ
     VPGLDGRLFT QNFANHIQEL DPFDLTPTQV QTWDEINADF KGYSSSPNGQ VDPETGEYIN
     FTMEIGYRTT RYHFFSISNQ EPKGHPITTI WNAPTGWVNG FALTPNYIVM VIHPMLANSG
     AVRFAWNESV LDSFTFYPSE PTLFYVISRV DKEVIACYRS NACFSLNQVN AYEDVHGNVT
     VDMVCYEDDT IVHRFATEKM RDADMERLPS SEVRRFVLAN PRHEANKIYL DNNSYIPSAI
     SVTSRIGTVW NYVTGQAGQP ENATGSAGWH AWMPVVKYER ISEATLELPQ VNPLYKMRKY
     SFAYGLGNTG NSKMWDSIIK LDVNNSTVVA SWHEANCYPS EAQFIPKPKD QAAEKDEEED
     SGVLISVVMD AARNTSFLLV LNAQDLSVIA KSQLNKLIPL SFAHGSYRLR STS
//