ID I1CH21_RHIO9 Unreviewed; 1482 AA.
AC I1CH21;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN ORFNames=RO3G_12462 {ECO:0000313|EMBL:EIE87751.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE87751.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE87751.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH476741; EIE87751.1; -; Genomic_DNA.
DR STRING; 246409.I1CH21; -.
DR VEuPathDB; FungiDB:RO3G_12462; -.
DR eggNOG; KOG0017; Eukaryota.
DR InParanoid; I1CH21; -.
DR OrthoDB; 3616499at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00024; CD_CSD; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 1140..1300
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1398..1456
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 296..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1482 AA; 170069 MW; 5278DFF70A404162 CRC64;
MVLDSFLTPS SSTGEREELL LRQNLTQLHS EFNGFLEAFT TARLAGDEAA ADHALQQMDR
TKRRLTAMQE YSSILGKTAS PNANISGRNA GLTSSHRDLP KFQLASSVVR PFPNEEVFES
VEHFLARFEN IIKGSAYRDV EQVWKQFLPL CLPYSDNAWV ETDLRKCNTW AEARAAFKEH
HGSSLATRHY TDLVFTMQMS NKESIGDYSK KFLQAVYNAG LPSDDPRIAD RFLASLTLSV
QMLMRVTVAR VGKSKIDTNE KWTVEYITQV GRDILGDDNK LYAEATALIP GANKSDTVKS
RYNENGSRGD GSLSGHRRHQ FKRRSRNMTK VNKNYFCTHH GKNGTHDTVD CFTTKRVEKV
NTNKKCFKCG QPWSREHKCK NNDKKVFAVT SHKNDNNPDD DAVKDKTALL DQATSEVNTM
MEGLSYDCKY QNKERTLDKK EIKANAFNLL TPIIIENEKL MGLVDTGSDT SFIDINAFTK
KLKLNKISGS YNFLSHNNDV SRIGITDPLK FKYSNGIMFE HSLEIMKFNT GFDFDVLLGT
DILPKMNIGL TGVAFRLSSE HSRSDTVTDE IQILENINID QVNEFEPDNS PAGTAEQRAN
FFDTIKDVLK KNQSIPVTSS CPMPESIIHL PTKEGATAYR RQYPIPHALR PVLDKQIEEW
LKTGTIIKSK VNTSFNSPLL LVPKRNKAGE IINHRVCLDV RLLNNILPPT FNYPVPLIRD
IFDNLSGKKV FSTIDLSNAY HRFKFAPEDV HKLTFTHDNA QYSFIKGCFG VKMLTSQFQK
CLAILFDGIS CVQNFVDDCI VASDSFEQHA EDVKLVLEKL TSVNLIVNPD KCVWFQHSVR
LLGFVVNTTG TKVDRNKLTN AQNWPIPNQS HKHVQQFMGL INYFRDYVPM ISRVAEPITR
LSNAVNIREL WTDEQTNSFN ALKAILQSNL ILHYPDLSKK FFVATDASLY GVAAVLYQKD
ELQRDKYISF VSSSLTPSQR RWSTTKRELY AIILALKKYR KFLWGKHFTI YSDHKALVYL
HTQKIANPMM IGWMETLLDF DFDVVRIPGV LNKLPDQLSR LYPPLEDDNK LVEDNVYKKN
KNRLKIKKVV VKRKKYCRDK SINVLATRLI ENKNELTDYL TPPEEERDAI LRETHSYGHY
GYQAIVRDIH SRDLAGPLPA TGDDYIYLLV LTDICTKYIV IRPLKNKQSD TVAKELISIF
GDYGFPRIIQ SDNGTEFRNS LMSHISKNLG IDRRYSTAYH PQGNGSSEAS VKIAMNTLRK
MIQSNGRDWN HYLPIVQLCI NRYIKNKTLS SPFSLMYARR VNMPDDYANK KYPIPNDLMT
VEELEERVKH MEEIVFPAIL ERTQKINEEY SPYTVVRKNR GGSYELKDEQ NELLHRNYTP
SELKVVNMDE SNIENEYYEV EEIRDHRGPI GHREFLVKWA GYGERANTWQ KASDFTDPTI
IEKYWDKQDE LKKLEHERAE HIVNKASSNS KYNESKEIPH LN
//