ID I1CH35_RHIO9 Unreviewed; 1063 AA.
AC I1CH35;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=chitin synthase {ECO:0000256|ARBA:ARBA00012543};
DE EC=2.4.1.16 {ECO:0000256|ARBA:ARBA00012543};
GN ORFNames=RO3G_12476 {ECO:0000313|EMBL:EIE87765.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE87765.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE87765.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-
CC D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) +
CC UDP; Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:58223; EC=2.4.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000319};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CH476741; EIE87765.1; -; Genomic_DNA.
DR AlphaFoldDB; I1CH35; -.
DR STRING; 246409.I1CH35; -.
DR VEuPathDB; FungiDB:RO3G_12476; -.
DR eggNOG; KOG2571; Eukaryota.
DR InParanoid; I1CH35; -.
DR OMA; WADISKN; -.
DR OrthoDB; 1331060at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004100; F:chitin synthase activity; IEA:UniProtKB-EC.
DR CDD; cd04190; Chitin_synth_C; 1.
DR InterPro; IPR004835; Chitin_synth.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22914; CHITIN SYNTHASE; 1.
DR PANTHER; PTHR22914:SF26; CHITIN SYNTHASE 7; 1.
DR Pfam; PF03142; Chitin_synth_2; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 143..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 860..881
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 887..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 958..1063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..999
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1052
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1063 AA; 119271 MW; A752BBE02AA3F237 CRC64;
MSPTRYDAPY GDGGGGQQYG YQPAMDNNDH YYNNQPMNNT NGVSIGRRAT TLGRAPTRRI
VPGANSIANA SSNIQRGRTL IRPDRYQEPP PLLTGKPTSN QSLFDPWVLF SRIVTFWALP
PMLRAFKMGD SGMQQAWREK ITLCFIIACM GGFVAFITIG LNSVLCPSDQ SNNQQNYATY
NDTNSANLLG ILGWQFNMSE SNPVSTIDFY ELAQIPGTDI TNYFTHGQNI PDCIHTGNSI
SSTFAAVNFS PCSTGTCIAG ELTAENFGLL GIFNSTKQVG FDWNQLASRN LSSYLVIDGN
VLNMGPYLQY YPTALANDAL DHIIRSVLNS AWAEGGRDGT KLFFRKPEYR AAVNCLVQKY
RAGHIDKKST GCFVASIILI CSLAIVLAIV LARFFMALIF SWFISRKLAR TPPPAPSSSG
SMTTIKNETM EMANMMQQRM DSGISSTLTA SAGKRVEVGN DLYTVLLITC YSENTEGIRG
TVESLSMTDY PDDRKLLFLI ADGIITGHGE TMSTPDMCLS LITFDDESMK NPEPMEYIAV
AVGAKQYNCA KVYAGYYVCK GHKVPMILVV KSGNPDEQGK PKPGNRGKRD SQLILMNFFS
RVTYNDRMTP LDYDLFRKIQ YLMGVTPDYF ELVLMVDADT KVYTSSMRLL VNCMVNDNLI
MGLCGETKIA NKRDSWVTAI QVYEYFISHH LAKGFEAIFG GVTCLPGCFC MYRLKARKGD
GDWVPIITKP EIVQEYSSNT IDTLHQKNLL LLGEDRFLTT LMLRNFPFRK MVFTPQAICK
TIVPDEFKVL LSQRRRWINS TIHNLFELVL VRNLCGTFCF SMQFVVMMDL VGTLTLPVAI
VLTAVLIISM AKTQITSISA AIPLILLIIV LFSPALLILI TTRKWVYLMW MIVYLFALPI
WNFVLPVYAF WHFDDFSWGE TRKVEGETKD DHSKKDGVFD PSKVPLKRWE DYERKRVRAN
KRRERKERQM REMMSPAHLT HAGVSPEDDE ARRGLLTTED DDMSQMSHLT DLSNNPPPAH
YFDPSKEAPA KAGSGYYPTY RPQSTAPEAM LGQHSPPSSM PRH
//
