ID I1CI14_RHIO9 Unreviewed; 628 AA.
AC I1CI14;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=HECT domain-containing protein {ECO:0000259|PROSITE:PS50237};
GN ORFNames=RO3G_12805 {ECO:0000313|EMBL:EIE88094.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE88094.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE88094.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH476742; EIE88094.1; -; Genomic_DNA.
DR AlphaFoldDB; I1CI14; -.
DR STRING; 246409.I1CI14; -.
DR VEuPathDB; FungiDB:RO3G_12805; -.
DR eggNOG; KOG0941; Eukaryota.
DR InParanoid; I1CI14; -.
DR OMA; FSSFKCE; -.
DR OrthoDB; 5471864at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 340..628
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
SQ SEQUENCE 628 AA; 72165 MW; 398B8581BA109B99 CRC64;
MSPNLTPSSS ADASSSESNN LTTLGSCMCC NSELRYPQTV SRFRCPGCDT INDLKPHIRD
QLSNQPLTLR SLKKAIYGCK QKEKTKKCSS DKERERIYEP IEELLENAFS SWVCLNHSFL
NPVNVIRAMM SATDRLLKRP AVPLRKMGDI RFLLIILENP LLAQHNFPAE TKYHHNLLKR
IFGILSCLNH ECHYALIKWL ASYPYKEFIA KIELIHSFLN HRISRARGNQ LNLSTFYESD
WKMASAARVM ALLYYIDLMG DFKSWQSVTG KFAFCQYPFL ISMGSKMKIV EIDAKQQMET
KWREAFFNML FYQKTSMPYL ILRVSRDNLI EDSLRQLAQN KLDLKKSLRI EFIGEEGVDA
GGLRKEWFLL LVRSLFDPQY SMFTYDEDSN LCWFNPASFE NEDQFFLVGV VLGLAIYNST
ILDIHLPTAC YKKLLNMPVG LSDLGSFRPA LKRGFDQLLE FDGDVENIFC RSFVAEIDKF
GQRICIPLIP NGEHIMVTKE NRQQFVSLYA DFVLNTSVER QFGAFKRGFY HVCGGNALSI
FQPEEIELLV RGSDGPLEID DLKSQTEYIG FDENEETIIN FWSIIKAMEP KMQRKLLMFV
TGSDRIPATG ATQMHLKITC GNNGDSDR
//
