ID   I1CKE1_RHIO9            Unreviewed;       832 AA.
AC   I1CKE1;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|Pfam:PF03810};
GN   ORFNames=RO3G_13632 {ECO:0000313|EMBL:EIE88921.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE88921.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE88921.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC       subfamily. {ECO:0000256|ARBA:ARBA00038423}.
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DR   EMBL; CH476743; EIE88921.1; -; Genomic_DNA.
DR   AlphaFoldDB; I1CKE1; -.
DR   STRING; 246409.I1CKE1; -.
DR   VEuPathDB; FungiDB:RO3G_13632; -.
DR   eggNOG; KOG2023; Eukaryota.
DR   InParanoid; I1CKE1; -.
DR   OMA; XYMLQRT; -.
DR   OrthoDB; 276400at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138}.
FT   DOMAIN          4..44
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03810"
FT   REGION          285..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..302
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   832 AA;  93375 MW;  BDEE14672A9955F6 CRC64;
     MPQEDQYIRS VAGLTLKNNI RSYYPTIPPQ VLEFVKECCL QHIGDSEVGK AVSLVIAAIV
     QRGQIQNWPQ AIQVLLEKLD DPSPVVVENA FSTFQKICED SARDLDTVIG GVQPLEFMIP
     KFIAFFDHPN HKIRLSAISS TSQFITLRSQ PLMNRVNEFL VALFKRATDD NVDVRKAVCQ
     SLVALLEMCP DVLLPHMPDL VEYMLFCTQS DDADLALEAC EFWLVFAEQD ELREQLHPYL
     QKVVPVLLKG MVYSEMDLLT LGGDEDDAHI ADSEQDVKPR FHKANVVEHS DQDEKKAGMP
     NNEEEGDDDD EDDDEFDEFE DDEFYEVVHI LIPLLKGELE SADWLHRECG ILALGAAAEG
     GIAEIAPHLH ELVPYLLNNL NDPKPLVRSI TCWTLGRFAS WIVSTSQQSP EARQRFLEPL
     IQLLLQRVLD NNKRVQEAAC SSLSLLEEEA TMELVPYLLP ILTTLSAAFE KYQHRNLLLL
     YDTVGTLADV VGETLNNQQF IDLIMPPLIR KWQAISDDNT DLFPLLECLS SITTALGKGF
     KPFAEPVYRR CVMLVLKTLE ECQAFAMDPS LDEPDKDFMI VALDLLSGIV QALNADAEPL
     VASTNPPVVQ FLSICIQDEV AEVRQSAYAL LGDLAISCFE HIRAVVPQFM PHILQQIDPQ
     AEHLSVCNNA TWAAGEIALK WGAEIRDYVE SLLQRLLPLI VNPQLQRTLL ENVAITTGRL
     GLVCPDLVAP HLQMFVKPWL NSLAPIRPNE EKSTAFSGLC EMIKVNPQGA VQEFPLLCHA
     IVNYQNAPAG LHESFRNILM GYKSMFGEAQ WQQVQASMPP ELIAPLHERY SI
//