ID I1CMB6_RHIO9 Unreviewed; 596 AA.
AC I1CMB6;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=RGS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=RO3G_14307 {ECO:0000313|EMBL:EIE89596.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE89596.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE89596.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; CH476744; EIE89596.1; -; Genomic_DNA.
DR AlphaFoldDB; I1CMB6; -.
DR STRING; 246409.I1CMB6; -.
DR VEuPathDB; FungiDB:RO3G_14307; -.
DR eggNOG; KOG3589; Eukaryota.
DR InParanoid; I1CMB6; -.
DR OMA; CANNDDR; -.
DR OrthoDB; 1364107at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10845; REGULATOR OF G PROTEIN SIGNALING; 1.
DR PANTHER; PTHR10845:SF192; RGS DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 198..269
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 369..548
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 289..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 596 AA; 67636 MW; D94C8CCCFA5D74B8 CRC64;
MFSAVLLQTN LTDHRSLFRT YPYTFTTEEA VKVMSSLKFI HVLRQPDPSN PSHQIATRTT
TTFSMDAITA KNMLQFFLFA RLIQNATDST NWTVKDKGFW CPTLKGKHVL EEFADYTQVE
MTDNLIAALN APYMSPSFSG STGGRIITLD RLTDHDDQIT FSRANMTVAF KAMLSSLSMD
ALILDDVGGI ERKNLAQYQH TFLAVHCVEW LADRLTVMSR EEAETIAAEF VLFGWIALVL
DKSDKSITTK DEGVSFKTSR SATYYVTERG YIAAGWKIPK EEIIQPTSDL SFHSETSSQA
TTSSNHKIKR VDSGTSLVEQ LANTSLSKDV SALPPDTPIR PPSMSFTDSS MSHGSTSSTN
KDSSHYYTRL YNILETPLLR MYFRDFLKSN YCAENINFWV DHDRLVRNSF KSETTAEQLA
DCYSIYESYL SPNAEEDVNI DHTLRQEIIS YVQNVFVPVP HPPRNDKIPY FTTPILHHKP
ANPSDRFLLL PPQATVKQRT IIIRGVSPDR CLIKLLSMLG RVNEHVCKMM AEDSVPKFVK
TSRYKELQQH QQPKQNVIVS HEQTTEEDQD DLLMALSSTP PSRVSIEDQR QEIQIP
//
