ID   I1CP58_RHIO9            Unreviewed;      1310 AA.
AC   I1CP58;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   ORFNames=RO3G_14949 {ECO:0000313|EMBL:EIE90238.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE90238.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE90238.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
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DR   EMBL; CH476746; EIE90238.1; -; Genomic_DNA.
DR   STRING; 246409.I1CP58; -.
DR   VEuPathDB; FungiDB:RO3G_14949; -.
DR   InParanoid; I1CP58; -.
DR   OrthoDB; 3230768at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR   PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138}.
FT   DOMAIN          763..1044
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   COILED          2..29
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1310 AA;  151877 MW;  D14AF7F1C2167557 CRC64;
     MIQRLTQELA AARSEIEQLR TTTIQLQNQF NHERLTSNQP TPPVITNTQS SFDIPEPTPT
     ASPWRNPDQV RRLKESLMQQ RQQRRQQRQE AAARILQPPS ENQGFKYIYL PTKARVPIGQ
     LRSRLRKLDI NNNRILDIHY PDRNVVALLV HNDYADELRS HLQRFKVTLK DDFNPCDPKI
     LRDPQYADAS DEERANLAFM HHCNRMERAL RFIRTPVKFA VARYFYAQGW ISKQTLQENL
     PSNRRNNEPE SDPLCFEDEN MSTTDEYKNQ DLPSDEASRQ AIGPILNIVR SSSVLLLTET
     WLLNPLKYPT HWKQYHTYGI KTQPLATKGS QGISLLVNPD CKYHVHHFRT DDTPLSQYKL
     SFTIANVLIH CLYLPPHLDN QTVNQVLNSL PHTTSHTNTT IICGDFNARL GSIVGDHSTN
     SRGNLIISWI QRNNIILWNQ RLAYGQYTFM AHQGSSIIDL FMSTTELTGS SMRIRQDLSL
     DSNHKLVSLS FQINASIPQL PRHPRIIWNL GKLKDRNNHE VYLRRFQELS QPLLQYHEKH
     YYHMNNRHYA VDYIEKLNAD LCQAIYTSLD DSCGRVSHST DPLRDFWTDK LQEAYDYREL
     CYRKWRKAYG LNKLHYWLKH QEARATLRRL IAQLRRETWA TFCKQMASEE YTKAISKLSR
     IRKNRTLKPT FSTPEGPQHA AEIMASCLET TFSGDLLKNV QLYEIDTPIL PFEIDCPFTR
     DDINLAIRSL PVKKAPGIDH LRNEMLQPIS HLLAPILFHL FHMCWAWSYV PQTWRIAQVI
     PIYKKGSPSD PGNYRPISMT TIFRKILERC IQHILQTDGP PLDIAQGGFR ESRSALDQAL
     CLTEISHILR THYHVKPVLA FLDIKSAYDT VNRSFVWDTL SRYVSSPMLN LLRCLFDDVQ
     IEILLSNTTS RRFHPKTGVL QGSILSPYLY SIYINQLPAQ LRSQAITTDM SPLETIPLLN
     CLLYADDVVL IAERTTMTGL LRVPFKPGGY LDPDELIRRN SSKALATMNV LKSMGINPSG
     FSRLLSTRFY AHIVRPQLEY GLAINRFTNT QLKSIEDVQD TCIRTIYGAR GNTSTKVMLH
     LAKLPLMADR VHILQAQFLY RSLCLPDDAL LCRLLPHIRH IRGHQWFLLS KTPLWQSLPS
     TGEELDKHMF KTAKKRFLQQ SLEKRQQSGH YKLLSSCRRS VSLDPILWLP MSYAERSRCI
     RWRLGWLPGG KPHPCPKHPT LKFTRKHAIT CLNMHQRLYM PKTITDPLSF LLNMLPSRPS
     VSSNLALSWS QRWPVICSIL HELDQLQHVT AIPITHPHGQ KLLEWLKHFL
//