ID   I1CQ27_RHIO9            Unreviewed;      1517 AA.
AC   I1CQ27;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   ORFNames=RO3G_15268 {ECO:0000313|EMBL:EIE90557.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE90557.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE90557.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
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DR   EMBL; CH476746; EIE90557.1; -; Genomic_DNA.
DR   STRING; 246409.I1CQ27; -.
DR   VEuPathDB; FungiDB:RO3G_15268; -.
DR   eggNOG; KOG1075; Eukaryota.
DR   InParanoid; I1CQ27; -.
DR   OrthoDB; 2554779at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR   PANTHER; PTHR19446:SF479; RIBONUCLEASE H; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138}.
FT   DOMAIN          890..1180
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          76..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          785..830
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1079..1099
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          30..67
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1517 AA;  166613 MW;  B19CF708D527FCE6 CRC64;
     MGPLRKNLRS RIPNAAASTN SANSNADVTL QSLAAAYQDL TARLSALEQL QLENARLVEL
     TKNQANEIDS LRAQLAAQTA GTPMDTPSSN TAASSSASLA ANNGAKVTGS SPPLGTAAST
     WATVASRGSK SKLRRRAAAA RGFQPVTGEQ GFDYVYIPRS RKMSYTEARR RLGRLGVDTW
     RVLDVSFPAH SVVGLLVHLQ YKPALVALLE KAKIKVLDQF DPLDPNHLAD PAFASASLEV
     RQEKMAHISN ERCLRTLERL RYPVAVAVSR FFLANAMVSD EAVSDVLAPK QDRPVFPRHP
     DQADDEMLLD HNTCHYNASS VSASGMVPDL LTPSSPLVSY GSHGSHGPSA PSNNTSSLVP
     LTIGLWNANG LQASTVDDLL RHCQSFSLVF ITETWLLPPA RLPTSWQQFH LYGSPVAGQY
     RGSMGVSALV SPRCSLPVVE FPVNCKYALG LQLGRSLRLI CLYLPPSLPT AEVQSVLDSL
     PLTDDTIICG DLNARLGRLV GDSRTNMRSS VLRRWCDDHG LNILNKTLAY GIPTYLTCRG
     HAEVSSIVDY YITNMPLVHS ANISVALDLS LGSDHKLMSL SFEYSVPVVP STPSPSSGQV
     RRLWNLSRLK EPEVQKLYVS TFCSLSAALL DQLQQLCSSP PSTRPPIDHL NDELNAAIYS
     ALDKSVGSRT SRPKQWKRFW TSQLQALADR RDWLYRKWRW SLGIDKAYWW GLHQEAHVRF
     RTAVKRAKRE SWRAFCDSLA RGDFSAAVRR VKQVHNRRRP QVSYAHPDGP VAGANAMRDH
     LASVYSGSGL PSSRPPPLPS PDGHVPFDLG SVSEDSPSGS DLGSGLGSDS GLGLVPGSGS
     GLSSFSADSV ADTMRRLPLR KAPGSDHLRT EMLIPIRKQV AAILARLFDI CCQWSYTPSL
     WRHAQVVPIY KKGDPHQPSN FRPISLTSII RKLFEMCLFP FLEDVSPPLD IAQGGFRPQR
     SALDQALCLH DLMQEYYRRK RHFPVVAFLD IKAAYDTVDR RVIWQSLLAV NAPFALVSVL
     AHLFDDVSIS VLLSNQVSTP FTPSTGVLQG SVLSPHLYSI YINTLPALLR SAATRTTTMV
     SSLSPSGPPG PSDSGSSGSG LGLPFGPSLD VSSLSPSPTA INSLLYADDV AIIGSASEVK
     QMLDLAQIHS QVLGYRWSPT KCAILNAPDP TSSRYVRLTL YDEDIPSVDE FVYLGVPFVR
     NGISPSRLVA HRKPGAQLKM AQLSAIGANR SGFSLLFSSR LYAMFVRPKL EYGLAISKLL
     KKDYDELERA QSRCLRLIVG GHKTSSTVVL RHICNLPSMR FRADTLVLKF CLRAGTLPDD
     CLLSLLSSSL PSSLLSTLRS RRIVLDHPPE VTAPSRLKTW LHAYRQQEFD QFLASTQQVL
     IRACRPVLRV DPILYVPASR ADRSRLIRWR MGWLPGDPRP CACLFGHTTR AHLMVCPQVP
     SALWCCVPFL PAGSTELHID YLLSLLPVSP SARCPPFWVS LCTILWHFDR LCNPDGDYTN
     DPPPGLLWHE RSLSSSR
//