ID I1CUA3_RHIO9 Unreviewed; 1687 AA.
AC I1CUA3;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN ORFNames=RO3G_16744 {ECO:0000313|EMBL:EIE92033.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE92033.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE92033.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; CH476753; EIE92033.1; -; Genomic_DNA.
DR STRING; 246409.I1CUA3; -.
DR VEuPathDB; FungiDB:RO3G_16744; -.
DR eggNOG; KOG0017; Eukaryota.
DR InParanoid; I1CUA3; -.
DR OMA; IHANISH; -.
DR OrthoDB; 2056154at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 766..952
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1306..1464
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1603..1662
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1656..1687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1669..1687
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1687 AA; 188231 MW; B87063E5676DF281 CRC64;
MSNSNDFNSA AAGSSSSNDK TYPDNARRMS DVSTLSSEAQ SSGMTTSAVS SGSFEPRIAA
PSIHSSIEEL DSTIIGATQV ILNLSVRLLS TTPESEEDSM VRAKYEACSK DLERLVHTRD
LLQRAMTHAV PTAWTGAPQV APAALNVVPP NLPLMQWKGA VFDPSAPVSV DVKHCLKKFQ
DVMFAHGLDL DQHWLRLLPP CLSSSQRTWL DEYQEKEDVH TWSQFKKAFT GHYGVGSAEE
KATSTTELLR ISMTAAETVD QYVERFNNLR RLAQIQDRCV LTRCFLIGLQ ADIYKKVIVS
LANCTDAQKE SVDYVVKLAK TLYHSLYKVR RVANASHTSA GPSMVNDSSS SGRKKSSAFV
SGSAVRAAPY PKASRKYCSF HKTTTHSNDE CRAMKKSSSL SPSSGSTQVD VSSGSAASQW
NPRNQPSGLG RPCRSCGADN WRPGHRCKGK GRSTGSSADD SDLAGPSHLF RGMSRSPASS
LSSVASSGND VSASVGSSAT PTTSSSDASS GRKTDAAGPV VSVPDSSDDM DIDVAEALTV
AEAAQACKYI THHIFSKAPS NTNTLYVPII VEHIKTWAMI DTGSTFSCVS PSFCSSLGLV
PTPNPGSIKL GHNSSSIVSR LGIINLTVYY NQIRLPYEFE VFDFSSDVPI CLGLDILPKL
RIGLTGLATS WLNSNIPKIP DPVNPDDYKP NETPVGTKQE RQQLMSTIQP LLDANTSIPM
SSHCNLPGAI ITLDTEPNAF AYRRQPDIAI ANRKIMEDQI QTWLDDCVIE PAPSNTRFNN
PIFLVGKKDV NGLYTKKRAV IDPRMLNQLV KNVDRMPLPL ISDLHQRMGS ATIFTTFDIR
ACFHRFLIQE SDRPKTAFTH PFTGMQYQFR HCPFGLTSTG NIVQRVLTNL FADLPYTALY
IDDLCVFSSG DMNQHIEYVR EVLKRLTAAN LIINVEKTHF AQSCVNILGW TIGNNGSLIP
DQRKLTNIHS WPTPKTGRQV MSFLGFANYF RNSLPMFSRL TAPLDRLRSL NSLKGIWNET
HECSFRNIKD ALVNAPVIHI PNLKYPFYVA TDASAYGIGG VVYQVIDQVI QYNAFAARSL
SPTERRYHTN KRELLAIVFM FERYNKWLYN RHFTLTTDHK ALIYIKKQVV PNAAMLVWFE
TIFEYSFDIV HCPGIKNIIP DALSRLFPDD NKLEGGNNVN NVAIYSIRGK EKEKRKPTFK
EKSKSYETQT YAVTSATSSS SSKPLLHRAL QYEDYITPPP EERKDIILKA HLLGHYGIKA
IEQTIHGDKL HWTNLRQDIQ DVISKCHECK MFNIAKTGYH PPRSILPDGP LDHWVMDLGT
FNITSTSGNN FLLVMVDLFS RFTILKAIPD KQALTIAKQL VDIFCTFGWP KVIASDNGKE
FTATIVTELI NNSGIDKRVS NPFNPLGNSV NEAFVGIAKK TIVKQLQGRK EDWDLYVPAT
QYAMNLKYSR LHKSRPYTVI FNKVPNDMKD YSHIKPTLRS EAVDSKAIEN RLKYATEVVI
PALAKRIKET QDVDNAYFMK TNKIVHTPFP LHSEVMIKNV NKENKTDPYY EGPFYISGMT
TNGSYILVDK QNNLLSRDVP TSHLKLIALP SNKSAESIDD QHYEIQAIIQ HKGTPGNYQY
LVHWKGYDDP MDYTWEPTSS FDDRSSIETY WARRQAGNNT AVSKKARLPK RTVPTRDHHS
RSKRSRR
//
