ID I1CVJ2_RHIO9 Unreviewed; 925 AA.
AC I1CVJ2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=RO3G_16994 {ECO:0000313|EMBL:EIE92472.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE92472.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE92472.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG669511; EIE92472.1; -; Genomic_DNA.
DR AlphaFoldDB; I1CVJ2; -.
DR VEuPathDB; FungiDB:RO3G_16994; -.
DR eggNOG; KOG1134; Eukaryota.
DR InParanoid; I1CVJ2; -.
DR OMA; LWTHCLA; -.
DR OrthoDB; 366603at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 2.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 47..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 675..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 701..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..192
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 215..393
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 404..477
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 497..695
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 868..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 925 AA; 105678 MW; B692B7A880F550BB CRC64;
MPSNDISNTT SGFPCIGIFK FLCEEEEEPL PGSPAQTAKS PTGFTTQLIL CTSVGFACFL
LFCFLRVRWS NIYSPRLRMK KHAPEQLPTS FFGWIIPLLK TPNSVIMDKV GLDAVVMLQF
LLMSVKLFSF CGFFGTVVLY PISKMGGDFT NSTNPNKTTS TLTIDATHSV SFLWVYLFFT
YLFVFATFYF TFLNYRDYVR IRREFLLRKA KTLSARTLLV TGIPPHLRSD QKLAEYFEKL
GIGVVESVHT IRHVGRLLEF IKERTQYLRQ LETVYAKYLG NPSHVPHYDP DEFLSEDGPS
RLAIERDRPT VQESIFCGPQ LDAIDLYTKK FDQVDELVEK ARKVGKFAPT SVGFVTFEET
ISAYVASQVL IDSTPFRLRA QLAPEPRDVL WENIAMHGRE RLIRKVLVMF ILLFLVFSWS
IPCNYLSALT STKSLKAYFP WLLKLAEKNK ILNQIVAGFI PTLGVVIFFS VLPLIFNSKH
SYGKFKFVCI KGNFAIGLSV IEGFTTRSES EESCFAKQFF FLFFNVLLFI TVASTLFKSQ
KDIFEDPTKI ANIFASKLPE VAPFYINYTV LQGIMLCPIQ LLQIGPILVQ KFYCFFLCKT
PRDFAEVYAP RMYNFGWGYP VPVFMFVVVL VYSTISPLIL VFGVIYFAMC YLVCKYQLLY
VYFHSYEVAG RMWPMVFSRI IIALIIFELT SAGLFTLNKS FTMAILCVPL LFLTVIYKIV
MDKAYQQSTQ FLPLQLLSEK FGPMTTAAPI LNGGSSSHSS YKSHYQYSQN MIEEEEENNR
DKINRIRKRR TVLDEDDYVA EPRKTTDFRE PPMTLLTGIL NTGMKQYGHP ALLGVLPQLW
LPMKVDKAVS NSRGIADDEE FAIAIDHKKP MENQPLLPSS SSNDEEGGLT DEEEEEDNAN
AYFHHPERRL SRTSSKISYG TMHPS
//
