ID I1DTM3_9GAMM Unreviewed; 380 AA.
AC I1DTM3;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=RNAN_0369 {ECO:0000313|EMBL:GAB57401.1};
OS Rheinheimera nanhaiensis E407-8.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Rheinheimera.
OX NCBI_TaxID=562729 {ECO:0000313|EMBL:GAB57401.1, ECO:0000313|Proteomes:UP000004374};
RN [1] {ECO:0000313|EMBL:GAB57401.1, ECO:0000313|Proteomes:UP000004374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E407-8 {ECO:0000313|EMBL:GAB57401.1,
RC ECO:0000313|Proteomes:UP000004374};
RX PubMed=23209246; DOI=10.1128/JB.01922-12;
RA Zhang X.-Y., Zhang Y.-J., Qin Q.-L., Xie B.-B., Chen X.-L., Zhou B.-C.,
RA Zhang Y.-Z.;
RT "Genome Sequence of the Protease-Producing Bacterium Rheinheimera
RT nanhaiensis E407-8T, Isolated from Deep-Sea Sediment of the South China
RT Sea.";
RL J. Bacteriol. 194:7001-7002(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB57401.1}.
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DR EMBL; BAFK01000002; GAB57401.1; -; Genomic_DNA.
DR RefSeq; WP_008218162.1; NZ_BAFK01000002.1.
DR AlphaFoldDB; I1DTM3; -.
DR STRING; 562729.RNAN_0369; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000004374; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:GAB57401.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004374}.
FT DOMAIN 21..361
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 380 AA; 41609 MW; 6DC7A960BC5A4FF4 CRC64;
MSGANEVVLY QQLAAHNGKK IGVATLNSEK SLNALSLPMV ESLLPQLQAW QADNSISMVV
LQGAGDKAFC AGGDIRDLYK AMLDKPGEYA PYVEEFFTKE YTLDYLIHTF GKPVLVWGNG
IVMGGGLGLM AGASHRVVTA TSRIAMPEMA IGLYPDVGAS WFLNRMPAGC GLFLGLTGAS
INAADAKFIG LADHFLLHER KEALLEKLLS INWGETIALN HQKLSDLLRS EEEQCRTQMP
LSNIRPHQSA IEALAKHDSL QSVIAAVNAM PGEDKWLQKA KESLAYGSPI TAHIVFELLK
LGQSKILADS FRLELGLSVQ CGKLGEFTEG VRALLMDKDL QPKWQYKTVD EVPQPVIDEL
FRSPWAANEH PLRELGQLDN
//
