ID I1E1C2_9GAMM Unreviewed; 731 AA.
AC I1E1C2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN Name=relA {ECO:0000313|EMBL:GAB60100.1};
GN ORFNames=RNAN_3114 {ECO:0000313|EMBL:GAB60100.1};
OS Rheinheimera nanhaiensis E407-8.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Rheinheimera.
OX NCBI_TaxID=562729 {ECO:0000313|EMBL:GAB60100.1, ECO:0000313|Proteomes:UP000004374};
RN [1] {ECO:0000313|EMBL:GAB60100.1, ECO:0000313|Proteomes:UP000004374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E407-8 {ECO:0000313|EMBL:GAB60100.1,
RC ECO:0000313|Proteomes:UP000004374};
RX PubMed=23209246; DOI=10.1128/JB.01922-12;
RA Zhang X.-Y., Zhang Y.-J., Qin Q.-L., Xie B.-B., Chen X.-L., Zhou B.-C.,
RA Zhang Y.-Z.;
RT "Genome Sequence of the Protease-Producing Bacterium Rheinheimera
RT nanhaiensis E407-8T, Isolated from Deep-Sea Sediment of the South China
RT Sea.";
RL J. Bacteriol. 194:7001-7002(2012).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB60100.1}.
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DR EMBL; BAFK01000021; GAB60100.1; -; Genomic_DNA.
DR RefSeq; WP_008223341.1; NZ_BAFK01000021.1.
DR AlphaFoldDB; I1E1C2; -.
DR STRING; 562729.RNAN_3114; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000004374; Unassembled WGS sequence.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF40; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:GAB60100.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004374};
KW Transferase {ECO:0000313|EMBL:GAB60100.1}.
FT DOMAIN 400..461
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 656..731
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 731 AA; 82586 MW; 0F375B856F8456AF CRC64;
MVRVRQSHTT DYNSGETLEW LCSLGLTEKK ISSLMQAAEF LKQHQLTDSE TAVRHGWEMV
EILAELKMDS DSLQAALLFP LLDAGLISSV QVEAAFSSQV VSLLRSVQQM EAIRTIPTGP
NQSVNPQQAD NLRRMLLAMV EDVRAVVIKL AAQICYLREV KNADEETRVL AAKETNAIFA
PLANRLGIGQ LKWELEDLAF RYLHPQLYKQ IASLLEEKRL DREQYMQDFV ASVRQKMADA
NLQAEVYGRP KHIFSIWKKM QKKQLAFDQL YDIRAVRIIT ERVQDCYAAL GLVHTSWRHL
PKEFDDYIAT PKQNGYQSIH TVVLGPQGRP VEIQIRTRQM HEDSELGVAA HWRYKEGAAA
GKDGANDEKI GWLRKILQWQ EDVVDSSDLA EELRNQVIED RVYVFTPKGD IVDLPMGSTP
LDFAYYVHSN VGHRCIGAKV SGRIVPFTYQ LKTGDQVEIL TGREPNPSRD WLNPHLGYLK
SSRARSKVQY WFRLQDRDKN LAAGKELLDT ELTRLNLVME YPAKVLSRFN VNSMEELLVG
IGGGEIKVTQ VVHFIQSQYA KAEEPEIDPR LITKPLAPAK AKSDVVVQGV GNLLTHMAGC
CHPLPGDAII GYITQGRGIA IHRDDCDQFK TLQDSHPERV VDATWGDKYA SGYEVDIRIV
AHDRNGLLRD ITSILANEKA NVTKMSSSSD IKAQTAVINM TLELYNLDSL NKLLSKISQI
DDVVEAKRFH H
//
