ID I1E4X8_MOUSE Unreviewed; 754 AA.
AC I1E4X8;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Stromal interaction molecule 2 {ECO:0000313|Ensembl:ENSMUSP00000143855.2};
GN Name=Stim2 {ECO:0000313|Ensembl:ENSMUSP00000143855.2,
GN ECO:0000313|MGI:MGI:2151156};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000143855.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0007829|PubMed:19144319}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000143855.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000143855.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000143855.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000143855.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; I1E4X8; -.
DR SMR; I1E4X8; -.
DR jPOST; I1E4X8; -.
DR MaxQB; I1E4X8; -.
DR ProteomicsDB; 312023; -.
DR Antibodypedia; 10303; 322 antibodies from 37 providers.
DR Ensembl; ENSMUST00000201469.4; ENSMUSP00000143855.2; ENSMUSG00000039156.20.
DR AGR; MGI:2151156; -.
DR MGI; MGI:2151156; Stim2.
DR VEuPathDB; HostDB:ENSMUSG00000039156; -.
DR GeneTree; ENSGT00390000000214; -.
DR OrthoDB; 54068at2759; -.
DR PhylomeDB; I1E4X8; -.
DR ChiTaRS; Stim2; mouse.
DR Proteomes; UP000000589; Chromosome 5.
DR Bgee; ENSMUSG00000039156; Expressed in vestibular membrane of cochlear duct and 227 other cell types or tissues.
DR ExpressionAtlas; I1E4X8; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0015279; F:store-operated calcium channel activity; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl.
DR CDD; cd09574; SAM_STIM2; 1.
DR CDD; cd11722; SOAR; 1.
DR Gene3D; 1.10.238.180; -; 1.
DR Gene3D; 1.10.287.3550; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR032393; SOAR.
DR InterPro; IPR037608; STIM.
DR InterPro; IPR037610; STIM2_SAM.
DR PANTHER; PTHR15136:SF2; STROMAL INTERACTION MOLECULE 2; 1.
DR PANTHER; PTHR15136; STROMAL INTERACTION MOLECULE HOMOLOG; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF16533; SOAR; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:I1E4X8,
KW ECO:0007829|MaxQB:I1E4X8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 136..194
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 498..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 252..289
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 512..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 84771 MW; 6419255B270E2E63 CRC64;
MLLFGLLVAG VADGCDLVPR HLRGRRASGS AGAAASPSAA AAGERQALLT DPCMSLSPPC
FTEEDRFSLE ALQTIHKQMD DDKDGGIEVD ESDEFIREDM KYKDATNKHS HLHREDKHIT
VEDLWKQWKT SEVHNWTLED TLQWLIEFVE LPQYEKNFRD NNVKGTTLPR IAVHETSFMI
SQLKISDRSH RQKLQLKALD VVLFGPLTRP PHNWMKDFIL TISIVIGVGG CWFAYTQNKT
SKEHVAKMMK DLESLQTAEQ SLMDLQERLE KAQEENRTVA VEKQNLERKM MDEINYAKEE
ACRLRELREG AECELSRRQY AEQELEQVRM ALKKAEKEFE LRSSWSVPDA LQKWLQLTHE
VEVQYYNIKR QNAEMQLAIA KDEVAASYLL QAEKIKKKRS TVFGTLHVAH SSSLDEVDHK
ILEAKKALSE LTTCLRERLF RWQQIEKICG FQIAHNSGLP SLTSSLYSDH SWVVMPRVSI
PPYPIAGGVD DLDEDTPPIV PQFPGTVAKP AGSLARSSSL CRSRRSIVPS SPQSQRAQLP
AHAPLAAHPR HPHHPQHPQH SLPSPDPDIL SVSSCPALYR NEEEEEAIYF TAEKQWEVPD
TASECDSLNS SSGRKPSPPS SLEMYQTLSS RKISRDELSL EDSSRGESPV TADVSRGSPE
CVGLTETKSM IFSPASRVYN GILEKSCSMH QLSSGIPVPH PRHTSCSSAG NDSKPVQEAS
NVSRVSSIPH DLCHNGEKSK KPSKIKSLFK KKSK
//