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Database: UniProt
Entry: I1E4Y2_MOUSE
LinkDB: I1E4Y2_MOUSE
Original site: I1E4Y2_MOUSE 
ID   I1E4Y2_MOUSE            Unreviewed;       455 AA.
AC   I1E4Y2;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   16-OCT-2019, entry version 57.
DE   SubName: Full=Transcriptional regulator ERG {ECO:0000313|Ensembl:ENSMUSP00000113723};
GN   Name=Erg {ECO:0000313|Ensembl:ENSMUSP00000113723,
GN   ECO:0000313|MGI:MGI:95415};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000113723, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000113723, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000113723,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000113723}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000113723};
RG   Ensembl;
RL   Submitted (APR-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AC154330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC154691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC154818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; I1E4Y2; -.
DR   MaxQB; I1E4Y2; -.
DR   PRIDE; I1E4Y2; -.
DR   Ensembl; ENSMUST00000121809; ENSMUSP00000113723; ENSMUSG00000040732.
DR   MGI; MGI:95415; Erg.
DR   GeneTree; ENSGT00940000160662; -.
DR   ChiTaRS; Erg; mouse.
DR   Proteomes; UP000000589; Chromosome 16.
DR   Bgee; ENSMUSG00000040732; Expressed in 257 organ(s), highest expression level in brain blood vessel.
DR   ExpressionAtlas; I1E4Y2; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Proteomics identification {ECO:0000213|MaxQB:I1E4Y2,
KW   ECO:0000213|PeptideAtlas:I1E4Y2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN      113    199       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      287    367       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION       34     55       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION       72     92       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      217    280       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    238    259       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   455 AA;  51267 MW;  60FA0A7132D2A1F1 CRC64;
     MASTIKEALS VVSEDQSLFE CAYGTPHLAK TEMTASSSSD YGQTSKMSPR VPQQDWLSQA
     PARVTIKMEC NPSQVNGSRN SPDECSVNKG GKMVGSPDTV GMSYGSYMEE KHVPPPNMTT
     NERRVIVPAD PTLWSTDHVR QWLEWAVKEY GLLDVDVLLF QNIDGKELCK MTKDDFQRLT
     PSYNADILLS HLHYLRETPL PHLTSDDVDK ALQNSPRLMH ARNTDLPYEP PRRSAWTGHS
     HLTPQSKAAQ PSPSAVPKTE DQRPQLDPYQ ILGPTSSRLA NPGSGQIQLW QFLLELLSDS
     SNSNCITWEG TNGEFKMTDP DEVARRWGER KSKPNMNYDK LSRALRYYYD KNIMTKVHGK
     RYAYKFDFHG IAQALQPHPP ESSLYKYPSD LPYMGSYHAH PQKMNFVSPH PPALPVTSSS
     FFASPNPYWN SPTGGIYPNT RLPASHMPSH LGTYY
//
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