ID I1GVL8_BRADI Unreviewed; 328 AA.
AC I1GVL8;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=GDP-L-fucose synthase {ECO:0000256|ARBA:ARBA00012371};
DE EC=1.1.1.271 {ECO:0000256|ARBA:ARBA00012371};
GN Name=100839279 {ECO:0000313|EnsemblPlants:KQK16850};
GN ORFNames=BRADI_1g31027v3 {ECO:0000313|EMBL:KQK16850.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:KQK16850.1};
RN [1] {ECO:0000313|EMBL:KQK16850.1, ECO:0000313|EnsemblPlants:KQK16850}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK16850.1,
RC ECO:0000313|EnsemblPlants:KQK16850};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQK16850.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK16850.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK16850}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQK16850};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via
CC de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004883}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Fucose synthase subfamily. {ECO:0000256|ARBA:ARBA00005959}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000880; KQK16850.1; -; Genomic_DNA.
DR RefSeq; XP_003563327.1; XM_003563279.3.
DR AlphaFoldDB; I1GVL8; -.
DR STRING; 15368.I1GVL8; -.
DR EnsemblPlants; KQK16850; KQK16850; BRADI_1g31027v3.
DR GeneID; 100839279; -.
DR Gramene; KQK16850; KQK16850; BRADI_1g31027v3.
DR KEGG; bdi:100839279; -.
DR eggNOG; KOG1431; Eukaryota.
DR HOGENOM; CLU_007383_18_0_1; -.
DR InParanoid; I1GVL8; -.
DR OMA; HPSNYGY; -.
DR OrthoDB; 5474548at2759; -.
DR UniPathway; UPA00128; UER00191.
DR Proteomes; UP000008810; Chromosome 1.
DR GO; GO:0050577; F:GDP-L-fucose synthase activity; IBA:GO_Central.
DR GO; GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05239; GDP_FS_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR HAMAP; MF_00956; GDP_fucose_synth; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR028614; GDP_fucose/colitose_synth.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43238; GDP-L-FUCOSE SYNTHASE; 1.
DR PANTHER; PTHR43238:SF1; GDP-L-FUCOSE SYNTHASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810}.
FT DOMAIN 21..253
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 328 AA; 35581 MW; 3E58D588DD24E2FE CRC64;
MGTVTPADPH PSFLADKGAK VYVAGHRGLV GSAILRRLVS LGFTDVVVRT HAELDLTRQS
AVEAFFAAEL PRYVVLAAAK VGGIHANSTF PADFIAANLQ IQTNVVDAAL RCGSVRKLLF
LGSSCIYPKF APQPITEGSL LSGPLEPTNE WYAVAKIAGI KMCQAYRIQH GLDAISAMPT
NLYGPQDNFH PENSHVLPAL IRRFHEAKAT NAPEVVVWGS GSPLREFLHV DDLADAVIFL
MDQYSGLEHV NVGSGSEVTI KELAELVKEV VGFQGKLVWD SSKPDGTPRK LMDSSKIQGI
GWKPKVPLKE GLVETYKWYV ENVIAGKK
//
