ID I1H4H1_BRADI Unreviewed; 945 AA.
AC I1H4H1;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Glutamate receptor {ECO:0000256|PIRNR:PIRNR037090};
GN Name=100836921 {ECO:0000313|EnsemblPlants:KQK21239};
GN ORFNames=BRADI_1g59600v3 {ECO:0000313|EMBL:KQK21239.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:KQK21239.1};
RN [1] {ECO:0000313|EMBL:KQK21239.1, ECO:0000313|EnsemblPlants:KQK21239}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK21239.1,
RC ECO:0000313|EnsemblPlants:KQK21239};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQK21239.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK21239.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK21239}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQK21239};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as non-selective
CC cation channel. {ECO:0000256|PIRNR:PIRNR037090}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685, ECO:0000256|PIRNR:PIRNR037090}.
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DR EMBL; CM000880; KQK21239.1; -; Genomic_DNA.
DR RefSeq; XP_003561526.1; XM_003561478.3.
DR AlphaFoldDB; I1H4H1; -.
DR STRING; 15368.I1H4H1; -.
DR EnsemblPlants; KQK21239; KQK21239; BRADI_1g59600v3.
DR GeneID; 100836921; -.
DR Gramene; KQK21239; KQK21239; BRADI_1g59600v3.
DR KEGG; bdi:100836921; -.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_007358_0_1_1; -.
DR InParanoid; I1H4H1; -.
DR OMA; AYKKHQI; -.
DR OrthoDB; 1011589at2759; -.
DR Proteomes; UP000008810; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR CDD; cd13686; GluR_Plant; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF487; GLUTAMATE RECEPTOR 3.4; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 1.
DR PRINTS; PR01176; GABABRECEPTR.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037090-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|PIRNR:PIRNR037090};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037090};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037090};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037090}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..945
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014094295"
FT TRANSMEM 586..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 831..851
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 466..807
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT REGION 865..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 756..810
FT /evidence="ECO:0000256|PIRSR:PIRSR037090-50"
SQ SEQUENCE 945 AA; 101361 MW; 9BA22D47959033C6 CRC64;
MADLLLLLLR VLCLCSVVPL AVAAARPGNV TIGALFTFNS VIGRSAAAAI DLAVADVNRD
AAVLNGTRLS VVAQDTKCSG FVGTIQALQL MEKKVVAVVG PQSSGIAHVV SHVVNELHVP
LLTFAATDPA LASSQYPYLL RAARGDDASQ MAAVADIVAF YGWRQVAAVY ADTDHGRGGV
DALGDALEPH RARIALRAPF PPGAGSAAMA DLLVQVSLAE SRVIVVHVSP DSGLAVFSAA
RSLGMMAAGY VWIATDWLAA AIDSSSSSSH PANHPKSTMG LIQGVLTLRR YSPDSPAKRA
LAMASRSKHL NAYGLAAYDS VWTAARAIDA FLADGLDVTF SDDPRLQAEQ SGSNSTLRLG
ALKVFDQGPR LLEKLLLSNS TGITGALRFG ADRSLVDPVY EVLNVGGTGV RRVGFWSNRT
RLSLAAPDTK KNGSSSQQGL YSVIWPGETT ATPRGWVFPN NGRPLRIGVP WRTTYRQFVS
KDGTSPDGAS GYCVDVFKAA VSLLPYPVPF SFVLFGDGEK NPSYGDLVSK VANDEFDAAV
GDVSIVTNRT RVVDFTQPYV ESGLVIVSPV KEKNPNAWAF LKPFTGAMWA VTGAFFLFVG
AVVWVLEHRF NPDFRGSPRK QLVTIFWFSF STMFFAHREN TVSTLGRMVL IIWLFVVLII
NSSYTASLTS ILTVQQLSTG IQGLDGLIAS AEPIGYQVGS FAKSYMMEEL NVPESRLKEL
AIDDYASSLQ LGPHNGGVAA IVDELPYVDL FLSTNCQFKT VGQEFTKSGW GFAFQRDSPL
AVDLSTAILT LSENGDLQRI HDKWLNPGQC DGATQGADVT AAADRLNLGS FWGLFLISGV
ACFLALLVYF ARILCQYGKY KLAGGEPPGE DDPSSSSSSV SPERKPPVRR PERLRSIREL
MTFVDMKEAE VKRAIRRKSS DDGRRQPDRS IASSAGASSF SVSTV
//
