ID I1H681_BRADI Unreviewed; 340 AA.
AC I1H681; A0A0Q3KC64;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Nicotianamine synthase {ECO:0000256|RuleBase:RU368095};
DE EC=2.5.1.43 {ECO:0000256|RuleBase:RU368095};
GN Name=100826723 {ECO:0000313|EnsemblPlants:KQK21996};
GN ORFNames=BRADI_1g64500v3 {ECO:0000313|EMBL:KQK21996.2};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:KQK21996.2};
RN [1] {ECO:0000313|EMBL:KQK21996.2, ECO:0000313|EnsemblPlants:KQK21996}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK21996.2,
RC ECO:0000313|EnsemblPlants:KQK21996};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQK21996.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK21996.2};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK21996}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQK21996};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- FUNCTION: Synthesizes nicotianamine, a polyamine which serves as a
CC sensor for the physiological iron status within the plant, and/or might
CC be involved in the transport of iron. {ECO:0000256|RuleBase:RU368095}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-
CC methyl-5'-thioadenosine; Xref=Rhea:RHEA:16481, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17509, ChEBI:CHEBI:58249, ChEBI:CHEBI:59789; EC=2.5.1.43;
CC Evidence={ECO:0000256|RuleBase:RU368095};
CC -!- SIMILARITY: Belongs to the nicotianamine synthase (NAS)-like family.
CC {ECO:0000256|ARBA:ARBA00007009, ECO:0000256|RuleBase:RU368095}.
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DR EMBL; CM000880; KQK21996.2; -; Genomic_DNA.
DR RefSeq; XP_003561701.1; XM_003561653.2.
DR AlphaFoldDB; I1H681; -.
DR EnsemblPlants; KQK21996; KQK21996; BRADI_1g64500v3.
DR GeneID; 100826723; -.
DR Gramene; KQK21996; KQK21996; BRADI_1g64500v3.
DR KEGG; bdi:100826723; -.
DR eggNOG; ENOG502SMCB; Eukaryota.
DR HOGENOM; CLU_031919_0_0_1; -.
DR InParanoid; I1H681; -.
DR OMA; LEFTMLT; -.
DR OrthoDB; 2718460at2759; -.
DR Proteomes; UP000008810; Chromosome 1.
DR GO; GO:0030410; F:nicotianamine synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030418; P:nicotianamine biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004298; Nicotian_synth.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR32266:SF30; NICOTIANAMINE SYNTHASE; 1.
DR PANTHER; PTHR32266; NICOTIANAMINE SYNTHASE 3; 1.
DR Pfam; PF03059; NAS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51142; NAS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008810};
KW S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU368095};
KW Transferase {ECO:0000256|RuleBase:RU368095}.
SQ SEQUENCE 340 AA; 36242 MW; 8A1C9406F0546683 CRC64;
MEAQNKEAVD ALVQKITALH GAIAKLPSLS PSPVVNALFT ELVTACVPPS PVDVTKLGPE
AQRMREGLIR LCYEAEAKLE EHYSDMLAAF DNPLDHLAIF PYYINYINLS KLEYELLARY
APSCVAPAPA PCRVAFIGSG PLPLSSLLLA ALHLPAGTLL DNYDSCGAAN DRAIRLVRAD
SENLGARMSF HTAGVADLAE ELAAYDVVFL DALVGMTAEY KAKVIAHLGA HMADGAALVV
RSAHGARGFL YPVVDPEDLG RGGFEVLAVC HPGDDVINSV IIARKSDDMH ANGLHGRRGH
PPGPVPVVGT PCRFDKMAMG VTAEPRNQRA GGNKPFHADK
//