ID I1HQR5_BRADI Unreviewed; 429 AA.
AC I1HQR5;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=MHD domain-containing protein {ECO:0000259|PROSITE:PS51072};
GN Name=100835103 {ECO:0000313|EnsemblPlants:KQK09375};
GN ORFNames=BRADI_2g47620v3 {ECO:0000313|EMBL:KQK09375.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EnsemblPlants:KQK09375};
RN [1] {ECO:0000313|EMBL:KQK09375.1, ECO:0000313|EnsemblPlants:KQK09375}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK09375.1,
RC ECO:0000313|EnsemblPlants:KQK09375};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQK09375.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK09375.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK09375}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQK09375};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPI-coated vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004347}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004347}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004347}.
CC -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC {ECO:0000256|PIRNR:PIRNR005992}.
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DR EMBL; CM000881; KQK09375.1; -; Genomic_DNA.
DR RefSeq; XP_003569636.1; XM_003569588.3.
DR AlphaFoldDB; I1HQR5; -.
DR STRING; 15368.I1HQR5; -.
DR EnsemblPlants; KQK09375; KQK09375; BRADI_2g47620v3.
DR GeneID; 100835103; -.
DR Gramene; KQK09375; KQK09375; BRADI_2g47620v3.
DR KEGG; bdi:100835103; -.
DR eggNOG; KOG0937; Eukaryota.
DR HOGENOM; CLU_026996_0_0_1; -.
DR InParanoid; I1HQR5; -.
DR OMA; KPLIWCD; -.
DR OrthoDB; 5353102at2759; -.
DR Proteomes; UP000008810; Chromosome 2.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030663; C:COPI-coated vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR CDD; cd09250; AP-1_Mu1_Cterm; 1.
DR CDD; cd14835; AP1_Mu_N; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR001392; Clathrin_mu.
DR InterPro; IPR018240; Clathrin_mu_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR028565; MHD.
DR PANTHER; PTHR10529:SF262; ADAPTOR PROTEIN COMPLEX 1, MU SUBUNIT; 1.
DR PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR Pfam; PF00928; Adap_comp_sub; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PIRSF; PIRSF005992; Clathrin_mu; 2.
DR PRINTS; PR00314; CLATHRINADPT.
DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00990; CLAT_ADAPTOR_M_1; 1.
DR PROSITE; PS00991; CLAT_ADAPTOR_M_2; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|PIRNR:PIRNR005992};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005992}.
FT DOMAIN 171..427
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
SQ SEQUENCE 429 AA; 48933 MW; 53613A0F8CE5BFC1 CRC64;
MAGAVSALFL LDIKGRVLVW RDFRGDVTAV QAERFFTKLL DKEGDAEAHS PVVYDDAGVT
YMFIQHNNVF LLTASRQNCN AASILLFLHR VVDVFKHYFE ELEEESLRDN FVVVYELLDE
MMDFGYPQYT EAKILSEFIK TDAYRMEVTQ RPPMAVTNAV SWRSEGIRYK KNEVFLDVVE
SVNILVNSNG QIVRSDVVGA LKMRTYLSGM PECKLGLNDK VLLEAQGRAT KGKAIDLDDI
KFHQCVRLAR FENDRTISFI PPDGAFDLMT YRLSTQVKPL IWVEAQVEKH SRSRIEFMVK
ARSQFKERST ATNVEIEVPV PSDATNPNIR TSMGSATYAP ERDAMVWKIK SFPGGKEYMC
RAEFSLPSIA AEEGGPEKKA PIRVKFEIPY FTVSGIQVRY LKIIEKSGYQ ALPWVRYITM
AGEYELRLL
//
