ID I1HTD2_BRADI Unreviewed; 306 AA.
AC I1HTD2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=NADP-dependent oxidoreductase domain-containing protein {ECO:0000259|Pfam:PF00248};
GN Name=100822521 {ECO:0000313|EnsemblPlants:KQK10566};
GN ORFNames=BRADI_2g54900v3 {ECO:0000313|EMBL:KQK10566.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EnsemblPlants:KQK10566};
RN [1] {ECO:0000313|EMBL:KQK10566.1, ECO:0000313|EnsemblPlants:KQK10566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK10566.1,
RC ECO:0000313|EnsemblPlants:KQK10566};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQK10566.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK10566.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK10566}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQK10566};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
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DR EMBL; CM000881; KQK10566.1; -; Genomic_DNA.
DR RefSeq; XP_003564605.1; XM_003564557.3.
DR AlphaFoldDB; I1HTD2; -.
DR STRING; 15368.I1HTD2; -.
DR EnsemblPlants; KQK10566; KQK10566; BRADI_2g54900v3.
DR GeneID; 100822521; -.
DR Gramene; KQK10566; KQK10566; BRADI_2g54900v3.
DR KEGG; bdi:100822521; -.
DR eggNOG; KOG1577; Eukaryota.
DR HOGENOM; CLU_023205_0_0_1; -.
DR InParanoid; I1HTD2; -.
DR OMA; EHEIGNA; -.
DR OrthoDB; 1655661at2759; -.
DR Proteomes; UP000008810; Chromosome 2.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IBA:GO_Central.
DR CDD; cd19125; AKR_AKR4C1-15; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR044498; AKR4C.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR PANTHER; PTHR11732:SF500; NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008810}.
FT DOMAIN 31..277
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 51
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 113
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 80
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 306 AA; 33744 MW; 7D795D5344AA2B58 CRC64;
MAATAHFTLN TGARIPSVGL GTYKAAPGVV AGMLSSAVKA GYRHIDCAPL YKNEKEIGVA
LKNLFDDGVV KREDLFITSK IWCSDLAPED VPPAIDSTLK DLQLEYVDLY LIHWPFQVKK
GTEICPENFV QPDIPKTWQA MEQLYDSGKA RAIGVSNFSS KKLGDLLGVA RVPPAVDQVE
CHLGWQQAKL RAFCHSRGVH LSAYAPLGRM KDVASNPVVT TVAETLGKTP AQIALRWGLQ
QGQSVLPKSA NESRLKENID LFDWSIPESL CAQFSEIKQV KQIRGDSFVH PQSVYKTYEE
LFDGEI
//
