ID I1I4A4_BRADI Unreviewed; 348 AA.
AC I1I4A4;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=E2F/DP family winged-helix DNA-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=100840033 {ECO:0000313|EnsemblPlants:KQJ96871};
GN ORFNames=BRADI_3g27520v3 {ECO:0000313|EMBL:KQJ96871.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EnsemblPlants:KQJ96871};
RN [1] {ECO:0000313|EMBL:KQJ96871.1, ECO:0000313|EnsemblPlants:KQJ96871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQJ96871.1,
RC ECO:0000313|EnsemblPlants:KQJ96871};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQJ96871.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQJ96871.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQJ96871}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQJ96871};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- FUNCTION: Involved in the regulation of the G1/S transition. Increases
CC the DNA binding activity of E2F proteins after heterodimerization.
CC {ECO:0000256|PIRNR:PIRNR009404}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR009404,
CC ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|PIRNR:PIRNR009404, ECO:0000256|RuleBase:RU003796}.
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DR EMBL; CM000882; KQJ96871.1; -; Genomic_DNA.
DR RefSeq; XP_003573972.1; XM_003573924.3.
DR AlphaFoldDB; I1I4A4; -.
DR STRING; 15368.I1I4A4; -.
DR EnsemblPlants; KQJ96871; KQJ96871; BRADI_3g27520v3.
DR GeneID; 100840033; -.
DR Gramene; KQJ96871; KQJ96871; BRADI_3g27520v3.
DR KEGG; bdi:100840033; -.
DR eggNOG; KOG2829; Eukaryota.
DR HOGENOM; CLU_039874_2_1_1; -.
DR InParanoid; I1I4A4; -.
DR OMA; NDSADRG; -.
DR OrthoDB; 1343784at2759; -.
DR Proteomes; UP000008810; Chromosome 3.
DR ExpressionAtlas; I1I4A4; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd14458; DP_DD; 1.
DR Gene3D; 1.20.140.80; Transcription factor DP; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR038168; TF_DP_C_sf.
DR InterPro; IPR014889; Transc_factor_DP_C.
DR InterPro; IPR015648; Transcrpt_fac_DP.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12548:SF18; DP TF; 1.
DR PANTHER; PTHR12548; TRANSCRIPTION FACTOR DP; 1.
DR Pfam; PF08781; DP; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR PIRSF; PIRSF009404; Transcription_factor_DP; 1.
DR SMART; SM01138; DP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR009404, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|PIRNR:PIRNR009404, ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810};
KW Transcription {ECO:0000256|PIRNR:PIRNR009404,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR009404,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 91..179
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 186..346
FT /note="Transcription factor DP C-terminal"
FT /evidence="ECO:0000259|SMART:SM01138"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 348 AA; 37533 MW; 766E362463F3DDC4 CRC64;
MVPGARSTGG VAHSASNSAA NAGSPSGRSR PGKGAAAAAA TTSASTSTPA RGSTVARRLS
DLEIKGDGAP SPQTAASKKK KKGAHVVGPD KGNRGLRQFS MKVCEKVESK GRTTYNEVAD
ELVAEFSDPN SNIGSPDPDN PNTQQYDEKN IRRRVYDALN VLMAMDIIYK DKKEIQWKGL
PRTSMSDIDK LKIKLIGQKG RIDKKSAYLQ ELQDQYVGLQ NLVERNEQLY SSGDAPSGGV
ALPFILVQTR PHATVEVEIS EDMQLVHLDF NSTPFELHDD SFVLKAMGLS GKEETDGTLA
LVANGIERSS TPNVYPHRSP QPARRSGLRL QTSPPIPGIL KGRVKHEH
//
