ID I1IB41_BRADI Unreviewed; 921 AA.
AC I1IB41;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=100824722 {ECO:0000313|EnsemblPlants:KQK00129};
GN ORFNames=BRADI_3g47472v3 {ECO:0000313|EMBL:KQK00129.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:KQK00129.1};
RN [1] {ECO:0000313|EMBL:KQK00129.1, ECO:0000313|EnsemblPlants:KQK00129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK00129.1,
RC ECO:0000313|EnsemblPlants:KQK00129};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQK00129.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK00129.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK00129}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQK00129};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CM000882; KQK00129.1; -; Genomic_DNA.
DR RefSeq; XP_003575262.1; XM_003575214.3.
DR AlphaFoldDB; I1IB41; -.
DR STRING; 15368.I1IB41; -.
DR EnsemblPlants; KQK00129; KQK00129; BRADI_3g47472v3.
DR GeneID; 100824722; -.
DR Gramene; KQK00129; KQK00129; BRADI_3g47472v3.
DR KEGG; bdi:100824722; -.
DR eggNOG; KOG1978; Eukaryota.
DR HOGENOM; CLU_004131_0_2_1; -.
DR InParanoid; I1IB41; -.
DR OMA; RMRIIGQ; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000008810; Chromosome 3.
DR ExpressionAtlas; I1IB41; baseline.
DR GO; GO:0032389; C:MutLalpha complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:EnsemblPlants.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR GO; GO:0009555; P:pollen development; IEA:EnsemblPlants.
DR GO; GO:0048316; P:seed development; IEA:EnsemblPlants.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810}.
FT DOMAIN 220..340
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 712..869
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 359..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 921 AA; 101370 MW; 0BFAC0A80BB22039 CRC64;
MGGASPAIKP IGKSAVHRIC SGQVIFDLSS AVKELVENSL DAGATTVEVN LKAYGEEWFK
VADNGSGISP SNFQALALKH HTSKISDFSD LNSVVTFGFR GEALSSLCAL GKLTVETRTK
DESVGTHLEF EHSGVVISNR KIARQVGTTV TIEKLFSTLP VRGKEFSRNI RKEYGKVISL
LNAYALIAKG VRLLCTNTVG KNSKMVVLKT QGSSSLKDNI ITVFGLNTFK CLEPFNVTIL
EGCQVEGFLS KPGPGSGRNS GDRQFFYVNG RPVDMPKVTK LVNELYKSSN SKQYPVAVLN
FCIPTTSYDV NVAPDKRKIF FSSEQTILLS LREAIENLYN PQQCSFSINL IEDPEKEVDP
AIDEPHESTD LIETGNVSSP RNDDDKDETD SDDQDLPQNQ KASFSARRVA VGTASKDRSP
LPGDPATPVD RSWLSEFQHE QPKVFHAQVK KNPAGSYHDR TGLAAKSSPS TTVQSSLSNF
LSLNKRKHED SCNLLSEAPV LRRGTCSGQV RRTSSETSTP TILISGTSGI PNVNSDQETS
PLRHHSPQSF LPKRTEVSPH HSEPPNIESH STETPPLDPC SIPSTKSYVD QQNDQHNSNF
AAPDKYSEVE PINIPLPDAC GHDNGTTVCS TSVSYPVMQF TVAELRRRRK YSFTVSHKKG
VYCSNKTARF YKAATLDNYV PNDDEGKSNY LAAATNELDR LFSKDNFGEM EVVGQFNLGF
IIGKLDQDLF IVDQHAADEK YNFESLSQST TLNIQPLLHP LRLELSPEEE VIVSMNMTTI
RKNGFVLAED LHASPGNHYL LKAVPFSKNI TFGVQDMKEL ISMLTDSQGD CSIISSYKMD
KTDSVCPSRV RAMLASRACR MSTMIGDPLT KAEMKKILKN LTGLRSPWNC PHGRPTMRHL
ADLHTIKSQE SNQSGVKKLI G
//
