ID I1IH36_BRADI Unreviewed; 556 AA.
AC I1IH36;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Nucleobase-ascorbate transporter 3 {ECO:0008006|Google:ProtNLM};
GN Name=100826596 {ECO:0000313|EnsemblPlants:KQJ86120};
GN ORFNames=BRADI_4g03420v3 {ECO:0000313|EMBL:KQJ86121.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:KQJ86121.1};
RN [1] {ECO:0000313|EMBL:KQJ86121.1, ECO:0000313|EnsemblPlants:KQJ86120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQJ86121.1,
RC ECO:0000313|EnsemblPlants:KQJ86120};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQJ86121.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQJ86121.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQJ86120}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQJ86120};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; CM000883; KQJ86120.1; -; Genomic_DNA.
DR EMBL; CM000883; KQJ86121.1; -; Genomic_DNA.
DR RefSeq; XP_003578422.1; XM_003578374.3.
DR RefSeq; XP_010237107.1; XM_010238805.2.
DR AlphaFoldDB; I1IH36; -.
DR STRING; 15368.I1IH36; -.
DR EnsemblPlants; KQJ86120; KQJ86120; BRADI_4g03420v3.
DR EnsemblPlants; KQJ86121; KQJ86121; BRADI_4g03420v3.
DR GeneID; 100826596; -.
DR Gramene; KQJ86120; KQJ86120; BRADI_4g03420v3.
DR Gramene; KQJ86121; KQJ86121; BRADI_4g03420v3.
DR KEGG; bdi:100826596; -.
DR eggNOG; KOG1292; Eukaryota.
DR HOGENOM; CLU_017959_5_3_1; -.
DR InParanoid; I1IH36; -.
DR OMA; FMEHIGD; -.
DR OrthoDB; 345287at2759; -.
DR Proteomes; UP000008810; Chromosome 4.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015207; F:adenine transmembrane transporter activity; IEA:EnsemblPlants.
DR GO; GO:0015208; F:guanine transmembrane transporter activity; IEA:EnsemblPlants.
DR GO; GO:0015294; F:solute:monoatomic cation symporter activity; IEA:EnsemblPlants.
DR GO; GO:0015210; F:uracil transmembrane transporter activity; IEA:EnsemblPlants.
DR GO; GO:0098702; P:adenine import across plasma membrane; IEA:EnsemblPlants.
DR GO; GO:0098710; P:guanine import across plasma membrane; IEA:EnsemblPlants.
DR GO; GO:0035344; P:hypoxanthine transport; IEA:EnsemblPlants.
DR GO; GO:0098721; P:uracil import across plasma membrane; IEA:EnsemblPlants.
DR InterPro; IPR006043; NCS2.
DR NCBIfam; NF037981; NCS2_1; 1.
DR PANTHER; PTHR11119:SF29; NUCLEOBASE-ASCORBATE TRANSPORTER 3; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 556 AA; 60558 MW; 69861D561A56E305 CRC64;
MGEMNQPPPP PVGVPPPMGM QPMMNPPVGA GAMHPPHEQF HHLAYCVHSN PSWVQVAALA
FLHYLVMLGS TVMLASIIVP AMGGSPGDKA RVIQSFLFMG GINTLLQTLI GTRLPTVMNA
SFAFVVPVLS IAREVGQQDF PSNQQRFVHT IRTAQGALIV ASVLNMILGY STVWGAYAKK
FSPVIMTPVV CVVGLGLFQL GFPQVGKCVE IGLPMLILAV VVQQYVPHYF RHFHERTTFL
FERYSLLLCI TIVWAFAAII TAAGAYNHVS LKTQQHCRTD KSYLMSSAPW IKIPLPFQWG
TPIFTPGHSF GMMGAVLVSA FESTGAHFAT ARLAGATPPP AHVLSRSIGL QGIGMFLEGI
FAAPCGSSVS VENIGLLGLT KVGSRRVIQI STGFMIFFSI FGKFGAFFAS IPLPIFAAIY
CILFGIVAAV GISYGQFVNK NSMRNIYIIG LSLFLGISIP QYFSEYTASA GSGPARTNAG
WFNDIINTVF ASGPTVALMV ASLLDNTLEV RGHESDRGLS WFMPFLRRRK GYSDPRNEEF
YKYPIRVHSL IPSRFH
//
