ID   I1Q471_ORYGL            Unreviewed;       328 AA.
AC   I1Q471;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=GDP-L-fucose synthase {ECO:0000256|ARBA:ARBA00012371};
DE            EC=1.1.1.271 {ECO:0000256|ARBA:ARBA00012371};
OS   Oryza glaberrima (African rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX   NCBI_TaxID=4538 {ECO:0000313|EnsemblPlants:ORGLA06G0193400.1, ECO:0000313|Proteomes:UP000007306};
RN   [1] {ECO:0000313|Proteomes:UP000007306}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IRGC 96717 {ECO:0000313|Proteomes:UP000007306};
RA   Wing R.A., Yu Y., Rounsley S., Reddy-Marri P., Goicoechea J.L.,
RA   Sisneros N., Lee S., Song X., Angelova A., Kudrna D.P., de Baynast K.,
RA   Zuccolo A.;
RT   "The complete genome of Oryza glaberrima.";
RL   Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblPlants:ORGLA06G0193400.1}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via
CC       de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.
CC       {ECO:0000256|ARBA:ARBA00004883}.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. Fucose synthase subfamily. {ECO:0000256|ARBA:ARBA00005959}.
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DR   AlphaFoldDB; I1Q471; -.
DR   SMR; I1Q471; -.
DR   STRING; 4538.I1Q471; -.
DR   EnsemblPlants; ORGLA06G0193400.1; ORGLA06G0193400.1; ORGLA06G0193400.
DR   Gramene; ORGLA06G0193400.1; ORGLA06G0193400.1; ORGLA06G0193400.
DR   eggNOG; KOG1431; Eukaryota.
DR   HOGENOM; CLU_007383_18_0_1; -.
DR   OMA; HPSNYGY; -.
DR   UniPathway; UPA00128; UER00191.
DR   Proteomes; UP000007306; Unassembled WGS sequence.
DR   GO; GO:0050577; F:GDP-L-fucose synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05239; GDP_FS_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   HAMAP; MF_00956; GDP_fucose_synth; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR028614; GDP_fucose/colitose_synth.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43238; GDP-L-FUCOSE SYNTHASE; 1.
DR   PANTHER; PTHR43238:SF1; GDP-L-FUCOSE SYNTHASE; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          21..253
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   328 AA;  35715 MW;  87D1D0335D807119 CRC64;
     MGTVTTADPH ASFLADKGGK VFVAGHRGLV GSAILRHLVS LGFTNVVVRT HAELDLTRQS
     DVEAFFAAEL PRYVVLAAAK VGGIHANSTF PADFIAANLQ IQTNVVDAAL KCGSVRKLLF
     LGSSCIYPKF APQPIPENSL LSGPLEPTNE WYAVAKIAGI KMCQAYRIQH GFDAISAMPT
     NLYGPQDNFH PENSHVLPAL IRRFHEAKAS NAAEVVVWGT GSPLREFLHV DDLADAVIFL
     MDHYSGLEHV NVGSGSEVTI KELAELVKEV VGFQGKLVWD SSKPDGTPRK LMDSSKIQEM
     GWKPKVPLKE GLVETYKWYV ENVISAKK
//