ID I1RJR5_GIBZE Unreviewed; 941 AA.
AC I1RJR5;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Chromosome 2, complete genome {ECO:0000313|EMBL:CEF79040.1};
GN Name=FG04095.1 {ECO:0000313|EnsemblFungi:CEF79040};
GN ORFNames=FGRAMPH1_01T14473 {ECO:0000313|EMBL:CEF79040.1};
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533 {ECO:0000313|EnsemblFungi:CEF79040};
RN [1] {ECO:0000313|EnsemblFungi:CEF79040, ECO:0000313|Proteomes:UP000070720}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1
RC {ECO:0000313|Proteomes:UP000070720}, and PH-1 / ATCC MYA-4620 / FGSC
RC 9075 / NRRL 31084 {ECO:0000313|EnsemblFungi:CEF79040};
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2] {ECO:0000313|EnsemblFungi:CEF79040, ECO:0000313|Proteomes:UP000070720}
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1
RC {ECO:0000313|Proteomes:UP000070720}, and PH-1 / ATCC MYA-4620 / FGSC
RC 9075 / NRRL 31084 {ECO:0000313|EnsemblFungi:CEF79040};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PH-1;
RA King R., Urban M., Hassani-Pak K., Hammond-Kosack K.;
RT "A revised Fusarium graminearum genomic reference sequence using whole
RT shotgun re-sequencing.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEF79040.1, ECO:0000313|Proteomes:UP000070720}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1
RC {ECO:0000313|Proteomes:UP000070720}, and PH-1
RC {ECO:0000313|EMBL:CEF79040.1};
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
RN [5] {ECO:0000313|EnsemblFungi:CEF79040}
RP IDENTIFICATION.
RC STRAIN=PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084
RC {ECO:0000313|EnsemblFungi:CEF79040};
RG EnsemblFungi;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fungal Na(+)/H(+) exchanger family.
CC {ECO:0000256|ARBA:ARBA00005248}.
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DR EMBL; HG970333; CEF79040.1; -; Genomic_DNA.
DR RefSeq; XP_011321545.1; XM_011323243.1.
DR AlphaFoldDB; I1RJR5; -.
DR EnsemblFungi; CEF79040; CEF79040; FGRRES_04095.
DR GeneID; 23551361; -.
DR KEGG; fgr:FGSG_04095; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G14473; -.
DR eggNOG; KOG4505; Eukaryota.
DR HOGENOM; CLU_008635_0_0_1; -.
DR InParanoid; I1RJR5; -.
DR OrthoDB; 1607026at2759; -.
DR Proteomes; UP000070720; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0120029; P:proton export across plasma membrane; IEA:InterPro.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:InterPro.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:InterPro.
DR InterPro; IPR013928; Cation/H_antiporter_C.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004712; Na+/H+_antiporter_fungi.
DR PANTHER; PTHR31382; NA(+)/H(+) ANTIPORTER; 1.
DR PANTHER; PTHR31382:SF4; NA(+)_H(+) ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF08619; Nha1_C; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000070720};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..433
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 458..913
FT /note="Alkali metal cation/H+ antiporter Nha1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08619"
FT REGION 457..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..648
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..903
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 941 AA; 104083 MW; E2944F92906B1BD8 CRC64;
MAWSHLDITK PHLVYIILGG FTSLFMLCSS VIKERMYIGE ATVATLCGVI FGPHAANLID
PQSWGSTDIV TVEFSRIVLV VQCFAVGVEL PKFYMERHWK SVVFLLIPVM TFGWLITSLF
IFWMIPPLDW LDSLVVAACV TATDPVLASS VVGKGKFAKR VPKHLRDLLS AESGCNDGMA
FPFIYLSLYL IQFKRDAQDV SFHFVVYVLL YECIFGAIYG FVIGYIARHG IRYAEKRDLI
DRESFLVFYF VVALWCAGSG SILGMDDLLV GFAAGVGFSN DGWFGEKTEE SHVSNVIDLL
LNLTYFVYFG TIIPWEQFNN GVFGLVAWRL VVIAIFVLLF RRIPIMLALK PFIPDVKTWR
EALFAGHFGP IGVGAIFVAI LARAELEHEE PVPLAQLPPE NTEHYDLIYL VWPIVSFLVV
TSILVHGSSI AVFTLGKRIN TLSLTMSYTA APEDGPSWMN RLPRISSQSR SQARSISEAS
IDEEKGPQFP PDAAIPNSGP YSHLLRRQRD QNGSRSPSVV SRKRKNKNWD EDRGPGGPIA
QSAIFPQRQS STPMSPNEQH DQEEFPSQDN TESTLAADDS SKERNSDRIE QAGESPVGSS
GQKTPPQPVS IYEEGHEMIF ENQDGDVLDV EPAPDSHRED ENHVPITAVK PGHDKLWTVA
GFKKRVGEVY NTEMEKRKDK GQDRRHEPAR AYQFGNTIIV EDADGEVVKT YELPAAKGGD
SEAGPSTPGE KPAGKHGWAN FGGVFGGNHG NEQNNRKKSV AETQAADDKA IRFTIGGVGQ
RMTKEDFIRE VQKLDSRTRK EVVEQSDASQ AVKKVAKQDL PPETAVKAAK AAEHHAPENR
KGRSGSSASA AAPSSPAKPS EQQAETAIER KRRLAALSSQ EEEPKEETTE TPAERRRREA
ALGVGNQADD SDDEGTERVP PNRRGITFAD STRPGRGRRA Q
//
