ID I1T369_9VIRU Unreviewed; 1339 AA.
AC I1T369;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Envelopment polyprotein {ECO:0000256|ARBA:ARBA00015294};
DE AltName: Full=M polyprotein {ECO:0000256|ARBA:ARBA00031199};
OS Rio Claro virus.
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Ellioviricetes; Bunyavirales; Phenuiviridae; Phlebovirus;
OC Phlebovirus claroense.
OX NCBI_TaxID=2848418 {ECO:0000313|EMBL:AEL29686.1, ECO:0000313|Proteomes:UP000116944};
RN [1] {ECO:0000313|EMBL:AEL29686.1, ECO:0000313|Proteomes:UP000116944}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Palacios G., Savji N., Sze W., Hutchinson S., Tesh R.,
RA Travassos da Rosa A., Lipkin W.;
RT "Genetic diversity of the Phlebovirus genus.";
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Host Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004244}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004244}. Host endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004482}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004482}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
CC -!- SIMILARITY: Belongs to the phlebovirus envelope glycoprotein family.
CC {ECO:0000256|ARBA:ARBA00033745}.
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DR EMBL; HM566186; AEL29686.1; -; Genomic_RNA.
DR Proteomes; UP000116944; Genome.
DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.3770; -; 1.
DR Gene3D; 2.60.98.50; -; 3.
DR InterPro; IPR043603; Phlebo_G2_C.
DR InterPro; IPR010826; Phlebovirus_G1.
DR InterPro; IPR009878; Phlebovirus_G2_fusion.
DR InterPro; IPR009879; Phlebovirus_NSM.
DR Pfam; PF19019; Phlebo_G2_C; 1.
DR Pfam; PF07243; Phlebovirus_G1; 1.
DR Pfam; PF07245; Phlebovirus_G2; 1.
DR Pfam; PF07246; Phlebovirus_NSM; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host endosomal membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|ARBA:ARBA00022506};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host endoplasmic reticulum {ECO:0000256|ARBA:ARBA00023184};
KW Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000116944};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 717..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1302..1327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..136
FT /note="Phlebovirus nonstructural NS-M"
FT /evidence="ECO:0000259|Pfam:PF07246"
FT DOMAIN 288..826
FT /note="Phlebovirus glycoprotein G1"
FT /evidence="ECO:0000259|Pfam:PF07243"
FT DOMAIN 833..1154
FT /note="Phlebovirus glycoprotein G2 fusion"
FT /evidence="ECO:0000259|Pfam:PF07245"
FT DOMAIN 1169..1338
FT /note="Phlebovirus glycoprotein G2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19019"
SQ SEQUENCE 1339 AA; 148702 MW; B099763A63795602 CRC64;
MIYLPILLLL RLTAASFVLE STRPKGHSSK VCLSNTSSSK ILERYWDNLE QGMPNGPRMC
SIGSGESHLT SGANIKKLIR DVRDSPTALN VSCVVANQPE HSISIAFLEI PDDFIKPTSI
DCVTGESIRE VGTLDEAASP PDFHKPVIIE MDEDTDFLPP RVLPASNDIR PVTLDTRHGH
ITRDEEKIAL QLEVDTLRDQ LGVERRQIAE LNSIMQNTAN MADSEREQNQ KTISEKHRQI
HDQTRQIHEL EREIMRLSRP TTLPLLKTTL AVMTAVSLLP ASDAVLWPHT RNRIGSGLYK
MSDDDSVDCR PVNYLEGCYG FELLLDSSQY PFFSSHSTFR SLLEAVNDNI VNKNNEGICL
SNSSQKDPKC HSDKALMQAY CPNNFRSAHY IDDNGQLRGV VCKEGYEITE DCNFCRKIKK
SANQNKDVYK SSVQMQDIVC QPGGEAYDGP KIRPKGACFI GNRVFKKCKL MSKSYEVVPF
VTVPSKGKIY LDTMILKNEE VISEDSFVCY DHRGQEGGSV ATEQESRGLN AVRVSECKIV
NSAKTKKCSG DAVFCSKYKC ANEYPEVYCR HVPGAGNLKV LMSGQWIKPT CLGYEKVLVG
REQKLNAIQP QEECNTCNVK CLNDGIRIRS TGFKMYTAVA CAHGSCKTIT QKPSSEILVP
YPGITASSGG KIGITLSHDD SKVSAHLTAH CKGRDPCEVY SCFFCWENFL NYQCHNVLSA
LVSTMIIISL LWVSLSIIVK ILRRVKLIPS YVKNPLAWMI YLWTWTVRSL LAYFRRKIYS
LNHQIGWNGD IEMGENRPRR RVDNPLGLRN LVPLQRYSLL FMFLVMTVSA DACSQSVVAS
SKIVRCRVES SKTVCKVSGS VVLKAGVIGS DSCLIIKGSS EGQKALMTVR TISSELVCRE
GQSFWTGQFT PSCLSSRRCH LVGECVEKDC QSWRDNVTSG EFGALGDNEM MTENKCFEQC
GGLGCSCWNI NPSCLFVHTK LVSTRKEAVR VFSCSEWVHR VTLEITTPKK EKDTVILTNL
GSKFLSWGSI SLSIDAEAIT GSNSYTFLQS TTGGFALLDE GLQTIPREGY LGEIRCSSEA
AVINGHKSCL RAPNLVKYKP MTDIVECTTS LVDPFAVFLR GSLPQMREGM TFTSTKDKKS
VQAMSSYAIK AEINLLLDDY DVEFAEDVVN CEASFVNISG CYSCNLGALI CLTIKSPREG
TFSSHNSDST LVLATHTSAG TQDYCMMTHF NTPHVEEELT YSCGGDEKKI EITGTLIAML
PYDDRNTTGG DSTVVNPASS SWSFLEWFKG LFSWLGGPLK GFFVIAGYVI ASIILIILIL
MVLRFLVARL MAVILKKTK
//
