ID I1YH62_METFJ Unreviewed; 494 AA.
AC I1YH62;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Na+/H+ antiporter NhaD type {ECO:0000313|EMBL:AFJ02255.1};
DE Flags: Precursor;
GN OrderedLocusNames=Q7C_1100 {ECO:0000313|EMBL:AFJ02255.1};
OS Methylophaga frappieri (strain ATCC BAA-2434 / DSM 25690 / JAM7).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Piscirickettsiaceae; Methylophaga.
OX NCBI_TaxID=754477 {ECO:0000313|EMBL:AFJ02255.1, ECO:0000313|Proteomes:UP000009145};
RN [1] {ECO:0000313|EMBL:AFJ02255.1, ECO:0000313|Proteomes:UP000009145}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAM7 {ECO:0000313|EMBL:AFJ02255.1,
RC ECO:0000313|Proteomes:UP000009145};
RX PubMed=22815445; DOI=10.1128/JB.00726-12;
RA Villeneuve C., Martineau C., Mauffrey F., Villemur R.;
RT "Complete genome sequences of Methylophaga sp. strain JAM1 and Methylophaga
RT sp. strain JAM7.";
RL J. Bacteriol. 194:4126-4127(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter
CC family. {ECO:0000256|ARBA:ARBA00025753}.
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DR EMBL; CP003380; AFJ02255.1; -; Genomic_DNA.
DR AlphaFoldDB; I1YH62; -.
DR STRING; 754477.Q7C_1100; -.
DR KEGG; mec:Q7C_1100; -.
DR PATRIC; fig|754477.3.peg.1080; -.
DR eggNOG; COG1055; Bacteria.
DR HOGENOM; CLU_029697_0_0_6; -.
DR OrthoDB; 9772058at2; -.
DR Proteomes; UP000009145; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR InterPro; IPR045016; NhaD-like.
DR NCBIfam; NF038006; NhaD_1; 1.
DR PANTHER; PTHR43269; SODIUM/PROTON ANTIPORTER 1-RELATED; 1.
DR PANTHER; PTHR43269:SF2; SODIUM_PROTON ANTIPORTER 1-RELATED; 1.
DR Pfam; PF03600; CitMHS; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009145};
KW Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..494
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003654094"
FT TRANSMEM 40..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..302
FT /note="Citrate transporter-like"
FT /evidence="ECO:0000259|Pfam:PF03600"
FT DOMAIN 350..433
FT /note="Citrate transporter-like"
FT /evidence="ECO:0000259|Pfam:PF03600"
SQ SEQUENCE 494 AA; 54157 MW; ADE715C35C52792A CRC64;
MDRFNRRHVP SAILWFAALL SLMFSLPAVA AESQVALLDL TGHWVGFVAL AIFFVAYALV
ILEEEIHMRK SKPVIVAAGL IWALIAFVYA QQSDPVFHET AGIMIRHNLL EYVELFLFLL
AAMTFINTMG ERGIFDGVRA WLVNQGFSLR SIFWLTGLMA FLISPVADNL TTALLMATVV
MTVAAGNPKF IVLGCINIVV AANAGGAFSP FGDITTLMVW QKGVLDFHEF FALFLPALVN
WLVPAFILAF AIRNVASLPA QETVQLKPGA LVIVGLFIAT ITMAASGHHF LHLPPVLGMM
TGLGLLKLYG YWLKLQDQKL LSRTETDGET PFNLRDETQQ HAPFNIFKQL QQAEWDTLMF
FYGIILCVGG LGTIGYLSVG SELLYGDLGP TTANILIGVI SAVIDNIPVM FAVLSMMPEM
SHGQWLLVTL TAGVGGSLLS IGSAAGVAVM GQARGIYTFF AHLKWIWAIA LGYALSIWLH
LWWNARYFDA VPLT
//
