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Database: UniProt
Entry: I2AX57_FRANT
LinkDB: I2AX57_FRANT
Original site: I2AX57_FRANT 
ID   I2AX57_FRANT            Unreviewed;       275 AA.
AC   I2AX57;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   08-MAY-2019, entry version 44.
DE   RecName: Full=Urease {ECO:0000256|SAAS:SAAS00354677};
DE            EC=3.5.1.5 {ECO:0000256|SAAS:SAAS00354677};
GN   OrderedLocusNames=OOM_0197 {ECO:0000313|EMBL:AFJ42754.1};
OS   Francisella noatunensis subsp. orientalis (strain Toba 04).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=1163389 {ECO:0000313|EMBL:AFJ42754.1, ECO:0000313|Proteomes:UP000002869};
RN   [1] {ECO:0000313|EMBL:AFJ42754.1, ECO:0000313|Proteomes:UP000002869}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Toba 04 {ECO:0000313|EMBL:AFJ42754.1,
RC   ECO:0000313|Proteomes:UP000002869};
RA   Jonassen I., Nilsen F., Sridhar S., Sharma A., Kongshaug H.;
RT   "Whole genome characterisation of Francisella noatunensis subsp.
RT   orientalis.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+);
CC         Xref=Rhea:RHEA:20557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:16526, ChEBI:CHEBI:28938;
CC         EC=3.5.1.5; Evidence={ECO:0000256|SAAS:SAAS01119912};
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|SAAS:SAAS00608819};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3)
CC       from urea (urease route): step 1/1.
CC       {ECO:0000256|SAAS:SAAS00317636}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PROSITE-
CC       ProRule:PRU00700, ECO:0000256|SAAS:SAAS00548017}.
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000256|PIRSR:PIRSR611612-50}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases
CC       superfamily. Urease alpha subunit family.
CC       {ECO:0000256|SAAS:SAAS00849550}.
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DR   EMBL; CP003402; AFJ42754.1; -; Genomic_DNA.
DR   STRING; 1163389.OOM_0197; -.
DR   EnsemblBacteria; AFJ42754; AFJ42754; OOM_0197.
DR   KEGG; fna:OOM_0197; -.
DR   PATRIC; fig|1163389.3.peg.239; -.
DR   KO; K01428; -.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000002869; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-EC.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR017951; Urease_asu_c.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002869};
KW   Cytoplasm {ECO:0000256|PROSITE-ProRule:PRU00700,
KW   ECO:0000256|SAAS:SAAS00317631};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00700,
KW   ECO:0000256|SAAS:SAAS00321417, ECO:0000313|EMBL:AFJ42754.1};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00321440};
KW   Nickel {ECO:0000256|SAAS:SAAS00317628}.
FT   DOMAIN       77    275       Urease. {ECO:0000259|PROSITE:PS51368}.
FT   ACT_SITE    268    268       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR611612-52, ECO:0000256|PROSITE-
FT                                ProRule:PRU00700}.
FT   BINDING     167    167       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00700}.
FT   MOD_RES     165    165       N6-carboxylysine. {ECO:0000256|PIRSR:
FT                                PIRSR611612-50}.
SQ   SEQUENCE   275 AA;  29006 MW;  12A21D17CA66CE48 CRC64;
     MSQSPTAGNE VADLIITNAI VIDYTGIYKA NIGVKNGKIS AIGKSGNPNN CDGITNGLEI
     GANTEILSAE GKIIIAGGID SHIHFISPGQ IDEALHSGIT TMIGGGTGPN TGTNTTTCTP
     GEFNIQKMIE SVNDFPLNFD FMGKGNSSNY EALASQIKAG AMGLKLHEDW GSTPKAIDTC
     LKVADDYDVQ VAIHTDTLNE SGFVENTINA FKGRTIRTFH SEGAGGSHAP DIIKVTGIEN
     VLPSSTNPTL PYTKNTIEEH LDMLMVCHHL SANSF
//
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