ID I2B5U0_SHIBC Unreviewed; 489 AA.
AC I2B5U0; K6VY63;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Putative Na+/H+ antiporter {ECO:0000313|EMBL:AFJ45894.1};
GN Name=ibeT {ECO:0000313|EMBL:AFJ45894.1};
GN OrderedLocusNames=EBL_c07710 {ECO:0000313|EMBL:AFJ45894.1};
OS Shimwellia blattae (strain ATCC 29907 / DSM 4481 / JCM 1650 / NBRC 105725 /
OS CDC 9005-74) (Escherichia blattae).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shimwellia.
OX NCBI_TaxID=630626 {ECO:0000313|EMBL:AFJ45894.1, ECO:0000313|Proteomes:UP000001955};
RN [1] {ECO:0000313|EMBL:AFJ45894.1, ECO:0000313|Proteomes:UP000001955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29907 / DSM 4481 / JCM 1650 / NBRC 105725 / CDC 9005-74
RC {ECO:0000313|Proteomes:UP000001955};
RX PubMed=22843577; DOI=10.1128/JB.00829-12;
RA Brzuszkiewicz E., Waschkowitz T., Wiezer A., Daniel R.;
RT "Complete genome sequence of the B12-producing Shimwellia blattae strain
RT DSM 4481, isolated from a cockroach.";
RL J. Bacteriol. 194:4436-4436(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000256|ARBA:ARBA00038435}.
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DR EMBL; CP001560; AFJ45894.1; -; Genomic_DNA.
DR RefSeq; WP_002442265.1; NZ_BAHA01000015.1.
DR AlphaFoldDB; I2B5U0; -.
DR STRING; 630626.EBL_c07710; -.
DR KEGG; ebt:EBL_c07710; -.
DR PATRIC; fig|630626.3.peg.757; -.
DR eggNOG; COG1757; Bacteria.
DR HOGENOM; CLU_033405_1_1_6; -.
DR OrthoDB; 9762978at2; -.
DR Proteomes; UP000001955; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR004770; Na/H_antiport_NhaC.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR NCBIfam; TIGR00931; antiport_nhaC; 1.
DR PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR PANTHER; PTHR33451:SF3; MALATE-2H(+)_NA(+)-LACTATE ANTIPORTER; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001955};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 40..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 163..464
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 489 AA; 51375 MW; 41720CF198F7D767 CRC64;
MNATQHDKKT LSFGVALVPI AAMLGLLIVG YGVMGLRIEP LLLCAAAVAA GIAWWQGYRW
DDIIDSVVGK LAKAMPVIMI LICVGGLIGT WMFSGTIPYM VYWGLKLISP QYILIAAFFL
TSVVSVCTGT SWGSAGTVGV ALMGVAAGLD VSLAAAAGAV VSGAYFGDKI SPLSDSTNFA
AIVADTTLFE HIQHLLYTTI PSFLLAAVVY LVAGHSGMIG DVATPQRVTD IVSALEGLYY
FNIVLLLPPV LVLWGAIRKK PVIPLMLSAC VLAIILGVAL QGLSLRQGLD AFMDGFSITM
FPGETDAIIA DVPRLLNRGG MFSMMSTILL VFCAFSFAGA LTLTGALNII ISRLLTVIRS
VGGLIAATIG TTILVTGATS DGKLALLVPA ELFKDAYRRM GLDTKNLSRT IEDAGTVIEP
LLPWTSAGVY MATTLGVSTL DLLPWAVQCY AAIFFALIYG VTGFGIARLP ATDKAQAVPD
AAPLVAREQ
//
