ID I2BFK4_9VIRU Unreviewed; 166 AA.
AC I2BFK4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Sulfhydryl oxidase {ECO:0000256|RuleBase:RU371123};
DE EC=1.8.3.2 {ECO:0000256|RuleBase:RU371123};
GN Name=24L {ECO:0000313|EMBL:AFJ52307.1};
OS European catfish virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Pimascovirales; Iridoviridae; Alphairidovirinae; Ranavirus;
OC Epizootic haematopoietic necrosis virus.
OX NCBI_TaxID=84739 {ECO:0000313|EMBL:AFJ52307.1, ECO:0000313|Proteomes:UP000118593};
RN [1] {ECO:0000313|EMBL:AFJ52307.1, ECO:0000313|Proteomes:UP000118593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Valdeolmos {ECO:0000313|EMBL:AFJ52307.1};
RA Lopez-Bueno A., Mavian C., Alcami A., Alejo A.;
RT "Complete genome sequence of European sheatfish virus.";
RL J. Virol. 86:6365-6366(2012).
RN [2] {ECO:0000313|Proteomes:UP000149128, ECO:0000313|Proteomes:UP000149504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Horvath B.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AMZ04853.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=13051/2012 {ECO:0000313|EMBL:AMZ04853.1}, and 14612/2012
RC {ECO:0000313|EMBL:AMZ04989.1};
RX PubMed=27717748;
RA Feher E., Doszpoly A., Horvath B., Marton S., Forro B., Farkas S.L.,
RA Banyai K., Juhasz T.;
RT "Whole genome sequencing and phylogenetic characterization of brown
RT bullhead (Ameiurus nebulosus) origin ranavirus strains from independent
RT disease outbreaks.";
RL Infect. Genet. Evol. 45:402-407(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR';
CC Xref=Rhea:RHEA:17357, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:16520, ChEBI:CHEBI:17412; EC=1.8.3.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000999,
CC ECO:0000256|RuleBase:RU371123};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU371123};
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DR EMBL; JQ724856; AFJ52307.1; -; Genomic_DNA.
DR EMBL; KT989884; AMZ04853.1; -; Genomic_DNA.
DR EMBL; KT989885; AMZ04989.1; -; Genomic_DNA.
DR RefSeq; YP_006347615.1; NC_017940.1.
DR GeneID; 12977973; -.
DR KEGG; vg:12977973; -.
DR OrthoDB; 11919at10239; -.
DR Proteomes; UP000118593; Genome.
DR Proteomes; UP000149128; Genome.
DR Proteomes; UP000149504; Genome.
DR GO; GO:0016972; F:thiol oxidase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.120.310; ERV/ALR sulfhydryl oxidase domain; 1.
DR InterPro; IPR036774; ERV/ALR_sulphydryl_oxid_sf.
DR InterPro; IPR017905; ERV/ALR_sulphydryl_oxidase.
DR Pfam; PF04777; Evr1_Alr; 1.
DR SUPFAM; SSF69000; FAD-dependent thiol oxidase; 1.
DR PROSITE; PS51324; ERV_ALR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU371123};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU371123};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU371123};
KW Reference proteome {ECO:0000313|Proteomes:UP000149128}.
FT DOMAIN 40..144
FT /note="ERV/ALR sulfhydryl oxidase"
FT /evidence="ECO:0000259|PROSITE:PS51324"
SQ SEQUENCE 166 AA; 18447 MW; 8F9EE2B98D13F837 CRC64;
MRLGTCLFSL KRRTIKMHGC NCNRVSGHLS AVRSSGLENG PFGPSGFGPS MWFTMHSGAA
ERAIRGGYLT ENEKAAWESW LRNLWVCIPC ESCRRHYVGI INAVDFGSVN TGDKVFRLTV
DIHNMVNARL NKPHVTLQKA IRIYGLDTKL GPASTITFRA NTSTFN
//
