ID I2BFN4_9VIRU Unreviewed; 387 AA.
AC I2BFN4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=ribonucleoside-diphosphate reductase {ECO:0000256|ARBA:ARBA00012274};
DE EC=1.17.4.1 {ECO:0000256|ARBA:ARBA00012274};
GN Name=53R {ECO:0000313|EMBL:AFJ52337.1};
OS European catfish virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Pimascovirales; Iridoviridae; Alphairidovirinae; Ranavirus;
OC Epizootic haematopoietic necrosis virus.
OX NCBI_TaxID=84739 {ECO:0000313|EMBL:AFJ52337.1, ECO:0000313|Proteomes:UP000118593};
RN [1] {ECO:0000313|EMBL:AFJ52337.1, ECO:0000313|Proteomes:UP000118593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Valdeolmos {ECO:0000313|EMBL:AFJ52337.1};
RA Lopez-Bueno A., Mavian C., Alcami A., Alejo A.;
RT "Complete genome sequence of European sheatfish virus.";
RL J. Virol. 86:6365-6366(2012).
RN [2] {ECO:0000313|Proteomes:UP000149128, ECO:0000313|Proteomes:UP000149504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Horvath B.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AMZ04883.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=13051/2012 {ECO:0000313|EMBL:AMZ04883.1}, and 14612/2012
RC {ECO:0000313|EMBL:AMZ05019.1};
RX PubMed=27717748;
RA Feher E., Doszpoly A., Horvath B., Marton S., Forro B., Farkas S.L.,
RA Banyai K., Juhasz T.;
RT "Whole genome sequencing and phylogenetic characterization of brown
RT bullhead (Ameiurus nebulosus) origin ranavirus strains from independent
RT disease outbreaks.";
RL Infect. Genet. Evol. 45:402-407(2016).
CC -!- FUNCTION: Ribonucleoside-diphosphate reductase holoenzyme provides the
CC precursors necessary for viral DNA synthesis. Allows virus growth in
CC non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides
CC from the corresponding ribonucleotides.
CC {ECO:0000256|ARBA:ARBA00025523}.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase small
CC chain family. {ECO:0000256|ARBA:ARBA00009303}.
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DR EMBL; JQ724856; AFJ52337.1; -; Genomic_DNA.
DR EMBL; KT989884; AMZ04883.1; -; Genomic_DNA.
DR EMBL; KT989885; AMZ05019.1; -; Genomic_DNA.
DR RefSeq; YP_006347645.1; NC_017940.1.
DR GeneID; 12978003; -.
DR KEGG; vg:12978003; -.
DR OrthoDB; 4477at10239; -.
DR UniPathway; UPA00326; -.
DR Proteomes; UP000118593; Genome.
DR Proteomes; UP000149128; Genome.
DR Proteomes; UP000149504; Genome.
DR GO; GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-EC.
DR GO; GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd01049; RNRR2; 1.
DR Gene3D; 1.10.620.20; Ribonucleotide Reductase, subunit A; 1.
DR InterPro; IPR009078; Ferritin-like_SF.
DR InterPro; IPR012348; RNR-like.
DR InterPro; IPR033909; RNR_small.
DR InterPro; IPR000358; RNR_small_fam.
DR PANTHER; PTHR23409; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN; 1.
DR PANTHER; PTHR23409:SF18; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2; 1.
DR Pfam; PF00268; Ribonuc_red_sm; 1.
DR SUPFAM; SSF47240; Ferritin-like; 1.
PE 3: Inferred from homology;
KW Deoxyribonucleotide synthesis {ECO:0000256|ARBA:ARBA00023116};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000149128}.
SQ SEQUENCE 387 AA; 44199 MW; 39FED77D1809709E CRC64;
MFPHVTIVEK PGCGNCVTLK RALKEKSVPH TVMPYVPGVP GPYPITTVGG QRVGYREITK
ALAMDMFTTS KCFKPFRYAW AEDIRTKHEK VHWMETEINL RDDVTDWKSG VMTPGEKAFV
SCVLRLFTQL DVEVGALYLD HLTQVFRCNE IRNMLTSFAC REAIHQKAYS LLNDTLGMPD
CEYQAFADYE EMTDKLDFMR EMDCSTLPGL ARSLFRAVLN EGVSLFAAFV MLLTFQRRGK
MKGMGKVVEW SVRDENMHVE GVSKLFETLN SEYPWVVNED LIELFKEDSE RVAELEKAFV
DLVFQECGPV CGLEPKQVKD YVLYVINLRA SNMGLPRLIE RAPEACPIPW VKWLIDGADL
TNFFENHVTE YETGGLTGSW SYEPLDV
//
