ID I2BFU6_9VIRU Unreviewed; 137 AA.
AC I2BFU6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN Name=114L {ECO:0000313|EMBL:AFJ52399.1};
OS European catfish virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Pimascovirales; Iridoviridae; Alphairidovirinae; Ranavirus;
OC Epizootic haematopoietic necrosis virus.
OX NCBI_TaxID=84739 {ECO:0000313|EMBL:AFJ52399.1, ECO:0000313|Proteomes:UP000118593};
RN [1] {ECO:0000313|EMBL:AFJ52399.1, ECO:0000313|Proteomes:UP000118593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Valdeolmos {ECO:0000313|EMBL:AFJ52399.1};
RA Lopez-Bueno A., Mavian C., Alcami A., Alejo A.;
RT "Complete genome sequence of European sheatfish virus.";
RL J. Virol. 86:6365-6366(2012).
RN [2] {ECO:0000313|Proteomes:UP000149128, ECO:0000313|Proteomes:UP000149504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Horvath B.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AMZ04945.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=13051/2012 {ECO:0000313|EMBL:AMZ04945.1}, and 14612/2012
RC {ECO:0000313|EMBL:AMZ05081.1};
RX PubMed=27717748;
RA Feher E., Doszpoly A., Horvath B., Marton S., Forro B., Farkas S.L.,
RA Banyai K., Juhasz T.;
RT "Whole genome sequencing and phylogenetic characterization of brown
RT bullhead (Ameiurus nebulosus) origin ranavirus strains from independent
RT disease outbreaks.";
RL Infect. Genet. Evol. 45:402-407(2016).
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903}.
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DR EMBL; JQ724856; AFJ52399.1; -; Genomic_DNA.
DR EMBL; KT989884; AMZ04945.1; -; Genomic_DNA.
DR EMBL; KT989885; AMZ05081.1; -; Genomic_DNA.
DR RefSeq; YP_006347707.1; NC_017940.1.
DR GeneID; 12977885; -.
DR KEGG; vg:12977885; -.
DR OrthoDB; 9577at10239; -.
DR Proteomes; UP000118593; Genome.
DR Proteomes; UP000149128; Genome.
DR Proteomes; UP000149504; Genome.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF6; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000149128}.
FT DOMAIN 1..137
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 137 AA; 15165 MW; E94158BA169FC776 CRC64;
MGIGNNGDLP WHPARLCKDF KHFRALTATS SVRGKQNVVI MGRKTWFSIP EKNRPLRDRI
NVVLSRELKD PPSGAHHLAS DFSSTVELAT TTLADVADQI WVIGGSSLYG ELMESPGTKR
LFVTHVSTQF ACDTFLP
//
