ID I2F4W2_9BACT Unreviewed; 317 AA.
AC I2F4W2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Theronine dehydrogenase-like Zn-dependent dehydrogenase {ECO:0000313|EMBL:AFK06965.1};
GN ORFNames=Theba_1277 {ECO:0000313|EMBL:AFK06965.1};
OS Mesotoga prima MesG1.Ag.4.2.
OC Bacteria; Thermotogota; Thermotogae; Kosmotogales; Kosmotogaceae; Mesotoga.
OX NCBI_TaxID=660470 {ECO:0000313|EMBL:AFK06965.1, ECO:0000313|Proteomes:UP000002881};
RN [1] {ECO:0000313|EMBL:AFK06965.1, ECO:0000313|Proteomes:UP000002881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mesG1.Ag.4.2 {ECO:0000313|Proteomes:UP000002881};
RX PubMed=22798451;
RA Zhaxybayeva O., Swithers K.S., Foght J., Green A.G., Bruce D., Detter C.,
RA Han S., Teshima H., Han J., Woyke T., Pitluck S., Nolan M., Ivanova N.,
RA Pati A., Land M.L., Dlutek M., Doolittle W.F., Noll K.M., Nesbo C.L.;
RT "Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima
RT MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.";
RL Genome Biol. Evol. 4:700-708(2012).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; CP003532; AFK06965.1; -; Genomic_DNA.
DR RefSeq; WP_006486629.1; NC_017934.1.
DR AlphaFoldDB; I2F4W2; -.
DR STRING; 660470.Theba_1277; -.
DR KEGG; mpg:Theba_1277; -.
DR eggNOG; COG1063; Bacteria.
DR HOGENOM; CLU_026673_11_0_0; -.
DR Proteomes; UP000002881; Chromosome.
DR CDD; cd08242; MDR_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR031640; Glu_dehyd_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43350; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43350:SF2; PKS_ER DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF16912; Glu_dehyd_C; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002881}.
FT DOMAIN 23..122
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 142..315
FT /note="Glucose dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16912"
SQ SEQUENCE 317 AA; 34399 MW; AF35D4A98265B25B CRC64;
MKALVFDGTL KLLDVPLPVR WPGTSLVKVN LAGICNTDLE ITRGYMDYHG ILGHELLGTV
IESDSAILSG KRVTTEINIP CKTCDLCKQG LLKHCRNIKT VGISDYPGVF AEYAVLPDEN
LHVIPESVSS LKAVFTEPLA AAAQVFESVE LSPDQRVCLI GDGKLGLLIS MALSAKKIEH
RLVGKHSQRI GLLGSSSGAL FLSIDEAESY DRHFDIVIEA TGNSSGLAQA LRLVRPQGKI
VLKSTYQGIP SFDVTSVVVR EIELIGSRCG PFDKAISMLE EGTVDPTTLI ENIFHIDESL
KAFEAAKKSL KVIIRMD
//
