ID I2F619_9BACT Unreviewed; 331 AA.
AC I2F619;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Transcriptional regulator {ECO:0000313|EMBL:AFK07372.1};
GN ORFNames=Theba_1638 {ECO:0000313|EMBL:AFK07301.1}, Theba_1715
GN {ECO:0000313|EMBL:AFK07372.1};
OS Mesotoga prima MesG1.Ag.4.2.
OC Bacteria; Thermotogota; Thermotogae; Kosmotogales; Kosmotogaceae; Mesotoga.
OX NCBI_TaxID=660470 {ECO:0000313|EMBL:AFK07372.1, ECO:0000313|Proteomes:UP000002881};
RN [1] {ECO:0000313|EMBL:AFK07372.1, ECO:0000313|Proteomes:UP000002881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mesG1.Ag.4.2 {ECO:0000313|Proteomes:UP000002881}, and
RC MesG1.Ag.4.2 {ECO:0000313|EMBL:AFK07372.1};
RX PubMed=22798451;
RA Zhaxybayeva O., Swithers K.S., Foght J., Green A.G., Bruce D., Detter C.,
RA Han S., Teshima H., Han J., Woyke T., Pitluck S., Nolan M., Ivanova N.,
RA Pati A., Land M.L., Dlutek M., Doolittle W.F., Noll K.M., Nesbo C.L.;
RT "Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima
RT MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.";
RL Genome Biol. Evol. 4:700-708(2012).
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DR EMBL; CP003532; AFK07301.1; -; Genomic_DNA.
DR EMBL; CP003532; AFK07372.1; -; Genomic_DNA.
DR RefSeq; WP_006489306.1; NC_017934.1.
DR AlphaFoldDB; I2F619; -.
DR STRING; 660470.Theba_1638; -.
DR KEGG; mpg:Theba_1638; -.
DR KEGG; mpg:Theba_1715; -.
DR eggNOG; COG1609; Bacteria.
DR HOGENOM; CLU_037628_6_1_0; -.
DR Proteomes; UP000002881; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR30146:SF152; HTH-TYPE TRANSCRIPTIONAL REGULATOR EBGR-RELATED; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR PRINTS; PR00036; HTHLACI.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000002881};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 2..58
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
SQ SEQUENCE 331 AA; 37105 MW; CBD7E2E8BF7247F4 CRC64;
MVTIKDVAAE AEVSIATVSR VLNGSGYVSE DTKLRVLRVI NRLNYHPMPS IRKKSLYRTL
GVLLPNTMGN HYGEIFMGVE DYAHKNGFNV MLAMAREMVS REQEILNEYF QRKVDGVIVA
TLHSDEHMLN RFIESGIVVV AVDSPIREIK ADSVNIDNSF AAYNVAKFLY EKGHRRVLFL
PGQEGVHASK DRLKGLRKFA SRTSDFDLKV ARIGGFEPHH GQEAIRDYLR DFGIDFTAIF
AVNDHVAMGA MQELHKNGVR VPDDVSVIGF DDSVHAPYTI PALTTVSQPR IEMGSAAAQL
LIERLRLTQK RVFRNIVLPT ALVERDSVKA I
//
