ID I2F7U0_9BACT Unreviewed; 1402 AA.
AC I2F7U0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=CoA-substrate-specific enzyme activase, putative {ECO:0000313|EMBL:AFK07993.1};
GN ORFNames=Theba_2373 {ECO:0000313|EMBL:AFK07993.1};
OS Mesotoga prima MesG1.Ag.4.2.
OC Bacteria; Thermotogota; Thermotogae; Kosmotogales; Kosmotogaceae; Mesotoga.
OX NCBI_TaxID=660470 {ECO:0000313|EMBL:AFK07993.1, ECO:0000313|Proteomes:UP000002881};
RN [1] {ECO:0000313|EMBL:AFK07993.1, ECO:0000313|Proteomes:UP000002881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mesG1.Ag.4.2 {ECO:0000313|Proteomes:UP000002881};
RX PubMed=22798451;
RA Zhaxybayeva O., Swithers K.S., Foght J., Green A.G., Bruce D., Detter C.,
RA Han S., Teshima H., Han J., Woyke T., Pitluck S., Nolan M., Ivanova N.,
RA Pati A., Land M.L., Dlutek M., Doolittle W.F., Noll K.M., Nesbo C.L.;
RT "Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima
RT MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.";
RL Genome Biol. Evol. 4:700-708(2012).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP003532; AFK07993.1; -; Genomic_DNA.
DR STRING; 660470.Theba_2373; -.
DR KEGG; mpg:Theba_2373; -.
DR eggNOG; COG1924; Bacteria.
DR eggNOG; COG3580; Bacteria.
DR eggNOG; COG3581; Bacteria.
DR HOGENOM; CLU_002393_2_0_0; -.
DR Proteomes; UP000002881; Chromosome.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 4.
DR Gene3D; 3.40.50.11900; -; 1.
DR InterPro; IPR002731; ATPase_BadF.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018709; CoA_activase_DUF2229.
DR InterPro; IPR008275; CoA_E_activase_dom.
DR NCBIfam; TIGR00241; CoA_E_activ; 1.
DR PANTHER; PTHR32329:SF7; ACTIVATOR OF 2-HYDROXYACYL-COA-HYDRATASE-RELATED; 1.
DR PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR Pfam; PF01869; BcrAD_BadFG; 2.
DR Pfam; PF09989; DUF2229; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023014};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW Reference proteome {ECO:0000313|Proteomes:UP000002881}.
FT DOMAIN 79..236
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
FT DOMAIN 288..539
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
FT DOMAIN 640..851
FT /note="DUF2229"
FT /evidence="ECO:0000259|Pfam:PF09989"
SQ SEQUENCE 1402 AA; 156917 MW; BC70824DBD00F705 CRC64;
MNRIGLCIGS STISWYDGQT PRRLLHEGNP LKVLKSFLPE ILETGLVVAT GKKGRKLLNL
PQIPEVEATE FAYKELKSKY GDHEAIMSVG GENFTLYKLN DKGNITAVFT GSKCASGTGE
FFLQQMKRMD IDLDDANAVE TDEIYELSSR CTVFCKSDCT HALNKGTPKE SVLNGLGKVM
SDKIGELMHR AGVKKILLVG GVTKNRLMLN HLKEIAEITI PDEALFFEAF GAYLYANTLE
EIEIDEESVF KEGVMTFPKN EPLSKFVNMV DFKDMPFKTA ESGDSCILGV DVGSTTTKAV
VMRARDNAIL ASSYLRTMGD PIKATRQCLD EIRNSLDVPV EIIGLGVTGS GRKIVGLYCE
TSAVYNEIMA HARAASFFDR EVDTIFEIGG QDAKYTFLSN GVALDYAMNE ACSAGTGSFL
EESAKESLNI DYREIGEYAL KGQSPPNFSD QCAAFISSDI KTAINEGISR EDICAGLVYS
ICLNYTNRVK AMRPVGKKVF MQGGVCLNHA VPVAMAAVTG KEIIVPPHPG LMGAFGVSLM
VKEKLQAGQL EEERFELGAL ISKEVRYLNT FICNGGAEKC DRKCPIRIIE VGGKKFPFGG
ACNKYENVRL NLPINRNEYI YTTDREKIVF ELPEEKGLET IGISKSLSMN TLFPLFSNFF
SSLGFRIVVP EKSDPRGWDR KKSEFCFPVE LSHGYIYDLL EKNPDYFFIP AVKGLEVANS
VENSVFCPFV QSEPDWLMGS FEELKSKRIL TDFFDFSRGF EKEKEKFVSL AKLLGRNRKE
ALTAFSNGVR SYEDSVRRIK EIGDRFLENL EKSDFGVVIF GRAYNAFSSD ANMGIPEKLA
SRGIPVVTFD ALPYENEKSY EKMYWAWGEM NLKAARYVRS NPKLFALYIT NFSCGPDSFL
ISFFRDIMGK KPSLILELDS HTSDAGVETR IEAFADVVRS SLERKTNLGE NNRAKRPKLL
TNNGTFSIEL QDGRHIPITD PSVKVIVPTM GEFAARLMAA AFEKVGINTH VLPRPTELEF
QLGKSNSLSK ECLPFHLTLG SLIRYLEENK DDESILMYFM PDTRGPCRFG QYSTYIDLWL
DKNNASNVLL FSLNSENGYA GIGLKAKLRI WASMIIADEF CNVENALLTL ASDRDEAVKA
TKDARKIILE SVRRDSFSEM TKKLEEICES ISHIPLKSDF ESAPKVLLSG EIYVRNDEFS
RKSLELFFAD NGIIMHASPI EEWIYYLDYI LLKKYVPTEL GPLKRGTKHV EILVKQAFEK
RIKKILEKSG LYKSHFVDIE SMVNTSKDFL NPKLTGEAIL TLGAVLFESI DTYDGVISIG
PFGCMPTRIA EAVAERGLEH LRENSSKLKR EIFKIAGNIP ILFFESDGNP FTPTVESRLE
SFVVQVKRVK SLSMELESQE FK
//
