ID I2F8P4_9BACT Unreviewed; 461 AA.
AC I2F8P4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Cysteine synthase {ECO:0000313|EMBL:AFK08297.1};
GN ORFNames=Theba_2698 {ECO:0000313|EMBL:AFK08297.1};
OS Mesotoga prima MesG1.Ag.4.2.
OC Bacteria; Thermotogota; Thermotogae; Kosmotogales; Kosmotogaceae; Mesotoga.
OX NCBI_TaxID=660470 {ECO:0000313|EMBL:AFK08297.1, ECO:0000313|Proteomes:UP000002881};
RN [1] {ECO:0000313|EMBL:AFK08297.1, ECO:0000313|Proteomes:UP000002881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mesG1.Ag.4.2 {ECO:0000313|Proteomes:UP000002881};
RX PubMed=22798451;
RA Zhaxybayeva O., Swithers K.S., Foght J., Green A.G., Bruce D., Detter C.,
RA Han S., Teshima H., Han J., Woyke T., Pitluck S., Nolan M., Ivanova N.,
RA Pati A., Land M.L., Dlutek M., Doolittle W.F., Noll K.M., Nesbo C.L.;
RT "Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima
RT MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.";
RL Genome Biol. Evol. 4:700-708(2012).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; CP003532; AFK08297.1; -; Genomic_DNA.
DR RefSeq; WP_014731991.1; NC_017934.1.
DR AlphaFoldDB; I2F8P4; -.
DR STRING; 660470.Theba_2698; -.
DR KEGG; mpg:Theba_2698; -.
DR eggNOG; COG0031; Bacteria.
DR HOGENOM; CLU_592863_0_0_0; -.
DR Proteomes; UP000002881; Chromosome.
DR GO; GO:1901605; P:alpha-amino acid metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.1100; -; 2.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR PANTHER; PTHR10314; CYSTATHIONINE BETA-SYNTHASE; 1.
DR PANTHER; PTHR10314:SF253; CYSTEINE SYNTHASE 1; 1.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 4: Predicted;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000002881}.
FT DOMAIN 78..359
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
SQ SEQUENCE 461 AA; 52570 MW; 43DE3ECDD584CA63 CRC64;
MGKFVLGPTF EEMLHPEKID RKTREIAWKM RKEDPLDPIN LYNISWRDID NRIYYFVLPK
EFTGVDANIV VLYGKDFPTG SHKVGATYSI LMEKVLRGEV DPTYHTLVWP STGNYGIGGA
WVGCRMKFDS VVILPEEMSA ERFNIIKEYG ARVFATPGCE SNVKEIYDKA KELKAANPEK
VRVLNQFDEL GNYRFHYYVT GNTILEMMDE LGLGNGRVSA VVATVGSAGT IACGDRIKEV
YPEVKIVAGE PVQCPTLSLN GYGGHDIQGI GDKHVTWIHN VMNNDAVVAL DDIECKKLLQ
VMTDEEGKKF LKEFLKADDV DTMADIFGIS GVANIVGAIK MAKYYKMSNK DNIVTIATDN
IDRYHSVMEN MSKTYGELTR DEARHRFESY VLGAKTDWIF EGTMDNRLRW HNLKYYTWVE
QQGRSVEELN KTMSQDFWKA ESGKIEEIDE LLLDYRVRNK E
//
