GenomeNet

Database: UniProt
Entry: I2G1N4_USTH4
LinkDB: I2G1N4_USTH4
Original site: I2G1N4_USTH4 
ID   I2G1N4_USTH4            Unreviewed;      1689 AA.
AC   I2G1N4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   05-JUN-2019, entry version 39.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=UHOR_02868 {ECO:0000313|EMBL:CCF53077.1};
OS   Ustilago hordei (strain Uh4875-4) (Barley covered smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=1128400 {ECO:0000313|Proteomes:UP000006174};
RN   [1] {ECO:0000313|EMBL:CCF53077.1, ECO:0000313|Proteomes:UP000006174}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Uh4875-4 {ECO:0000313|Proteomes:UP000006174};
RX   PubMed=22623492; DOI=10.1105/tpc.112.097261;
RA   Laurie J.D., Ali S., Linning R., Mannhaupt G., Wong P., Gueldener U.,
RA   Muensterkoetter M., Moore R., Kahmann R., Bakkeren G., Schirawski J.;
RT   "Genome comparison of barley and maize smut fungi reveals targeted
RT   loss of RNA silencing components and species-specific presence of
RT   transposable elements.";
RL   Plant Cell 24:1733-1745(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCF53077.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CAGI01000180; CCF53077.1; -; Genomic_DNA.
DR   STRING; 120017.I2G1N4; -.
DR   EnsemblFungi; CCF53077; CCF53077; UHOR_02868.
DR   Proteomes; UP000006174; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006174};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006174};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       74    215       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      799    983       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN     1050   1496       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1575   1644       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     26       Disordered. {ECO:0000256|MobiDB-lite:
FT                                I2G1N4}.
FT   REGION      222    244       Disordered. {ECO:0000256|MobiDB-lite:
FT                                I2G1N4}.
FT   REGION      314    344       Disordered. {ECO:0000256|MobiDB-lite:
FT                                I2G1N4}.
FT   REGION      429    449       Disordered. {ECO:0000256|MobiDB-lite:
FT                                I2G1N4}.
FT   REGION      472    642       Disordered. {ECO:0000256|MobiDB-lite:
FT                                I2G1N4}.
FT   COILED      761    781       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS     12     26       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                I2G1N4}.
FT   COMPBIAS    482    496       Acidic. {ECO:0000256|MobiDB-lite:I2G1N4}.
FT   COMPBIAS    514    536       Polar. {ECO:0000256|MobiDB-lite:I2G1N4}.
FT   COMPBIAS    561    579       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                I2G1N4}.
FT   COMPBIAS    580    642       Polar. {ECO:0000256|MobiDB-lite:I2G1N4}.
SQ   SEQUENCE   1689 AA;  190781 MW;  4C3F7219FF49C2D1 CRC64;
     MTTVDSAAPR DTARLPRTEK TDPTSSDPFF RVRLINIDHI LTVPGPLDRT QCAFNAEGQT
     LRKVPILRIF GATPAGQRVC LHIHNVYPYC YVQYKGSLDP GDALRYIHRL GRELNAAMAV
     SLRRNPDDPE ANQFIAAIHL CKGVNFYGYH VGYSYFLKIS FVDPSHNYRI ATILESGGVM
     KTIFQPFEIH IRYQLQFMLD YNIFGCDYVD LDDVSFRLPI PEGSTVASDE PSPPDSRRKI
     WDRNSIPYTH VQPEEVHRGT HCELEADASA PWIINRRRLK QRDLHRDFDE APNSGTEQNI
     LVPSLSGLWE GEKDRRAAAG LPPSIPTEDP SRDPRLYATG ESPPWNSEDR MRLLLKKRLI
     DEKQKTLPRE RAPNHFTDRS GLDHYIMTTF DAVEVFHPYQ DQIHAADPYS QRTGPSASSK
     LYDLQHVLSQ TQRGDSDQTD PPQLTQQMKG QPEDFDAKFF ESQEFTNRLN QAEMEDVAGN
     NDPPSDGEDE PTEGEAADPA ENVNDGQGPP RRWHCTESSD SNMSTSSTFS RSPSSTPKKR
     RYADVLGNTT KTPTMSPSSR LSREFHEDSV CKFKQAKHEH STGTTNGTNS TKSPPSATAG
     RSTRVRFASE SSPSPAETAK SNGSSTKRGS HTMTSVSETS PFNGSELGKR LFTFHEPAPS
     LKTVVETFSL FSIVRQVHLE PFFSDPNDVP ARPREYAGRM FQFQSRTLPY LHPFEHWHKS
     SADTSAQQGK PPRRLYWQFG PPPPTMLEAR AWRQREKIVE KQLSKRRRAR LLSQIERLTQ
     TNDYGFKISQ HKATTLVARD KQHMTILAVE VLTTTRGNLF PDPAFDPVQA IIYSFQNEDE
     NLQDTGSRPD LRTGLILVAN ENMNADRLGL SHLAVEVVED ELELFNTLID LIRAFDPEII
     VGWEIHSSSW GYIIERASKE YDFDLVPQLG RSVVHNTGRA GGKSDNYAYT QSSALRITGR
     HTLNLWRLMK GELTLNLYTL ENVCYHLLHR RMPKFSHQTL TQWFVSGRVE LMRKALLYFV
     DTVELELEII AESEFVLRTA EFARIYGIDF FSVISRGSQF KVESIMLRIA KPENFVLISP
     SRAQVGKQNA AECLPLIMEP QSAFYKGPLI VLDFQSLYPS IMIAYNLCYS TCLGRVAGFK
     GTSKFGVVDY APPKGLLSLL QDDVNISSNG LLFVKPHVRK SLLAKMLSEI LDTRVMVKGS
     MKGTKADKSF QRIQNARQLS LKLLANVTYG YTSASFSGRM PCVEIADAIV QTGRETLERA
     MDLINGTEEW GAQVVYGDTD SLFVYLPGRT KEEAFRLGNL IADKVTSLNP RPVKLKFEKV
     YLPSVLLAKK RYVGFKYETL DEREPGFDAK GIETVRRDFH PAIQRMLEAC IRILFRSRDL
     SIVKSYLQRQ WRKILEGRVS PQDFIFAKEV KLGSYSDKVA PPPGAAVSSR RMLADPRSEP
     QYGERVPYII SQGEPRAKLN QQAVSPDAFL KNPQLQINAM YYITRTIIPP LARVFNLLGA
     DVEGWFHEMP KPNNAYWNKR PTAALLSAVL EQQRLEGKAL DEEEPTSSPS IPKPIKTATS
     TTLTTLNSHY ATETCLLCSN RTEALVCIEC RQSPTDSMHS VASKLHRLEA QAVAIDRICS
     TCAGMERPEP VECVSLDCPY TYQKTKVKKA LEYTTLVHTY VARMFDAEGQ RVAAVRHAWS
     HIEDTSNDI
//
DBGET integrated database retrieval system