ID   I2GUN6_TETBL            Unreviewed;       863 AA.
AC   I2GUN6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=Probable vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|PIRNR:PIRNR007949};
GN   Name=TBLA0A00380 {ECO:0000313|EMBL:CCH57838.1};
GN   ORFNames=TBLA_0A00380 {ECO:0000313|EMBL:CCH57838.1};
OS   Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS   10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX   NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH57838.1, ECO:0000313|Proteomes:UP000002866};
RN   [1] {ECO:0000313|EMBL:CCH57838.1, ECO:0000313|Proteomes:UP000002866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC   UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- FUNCTION: Essential for vacuolar protein sorting. Required for vacuole
CC       biogenesis, stability and to maintain vacuole morphology.
CC       {ECO:0000256|PIRNR:PIRNR007949}.
CC   -!- SIMILARITY: Belongs to the VPS16 family.
CC       {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
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DR   EMBL; HE806316; CCH57838.1; -; Genomic_DNA.
DR   RefSeq; XP_004177357.1; XM_004177309.1.
DR   AlphaFoldDB; I2GUN6; -.
DR   STRING; 1071380.I2GUN6; -.
DR   GeneID; 14493154; -.
DR   KEGG; tbl:TBLA_0A00380; -.
DR   eggNOG; KOG2280; Eukaryota.
DR   HOGENOM; CLU_008909_1_0_1; -.
DR   InParanoid; I2GUN6; -.
DR   OMA; YVTFWYP; -.
DR   OrthoDB; 1110811at2759; -.
DR   Proteomes; UP000002866; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR   Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR   InterPro; IPR016534; VPS16.
DR   InterPro; IPR006925; Vps16_C.
DR   InterPro; IPR038132; Vps16_C_sf.
DR   InterPro; IPR006926; Vps16_N.
DR   PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR   PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR   Pfam; PF04840; Vps16_C; 1.
DR   Pfam; PF04841; Vps16_N; 1.
DR   PIRSF; PIRSF007949; VPS16; 1.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002866};
KW   Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT   DOMAIN          6..414
FT                   /note="Vps16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04841"
FT   DOMAIN          534..856
FT                   /note="Vps16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04840"
SQ   SEQUENCE   863 AA;  101200 MW;  59B81EFE998DE434 CRC64;
     MSIRNPSFNW EKLNNQFYRL RSINNDFQWP TNTTDFPSYQ IYVSTTLVAI YSKLDNHIQI
     LDHHSTPLFN LNTSIFGTVI SLQFNHNNEN LIIITNDSIH QIKNWTPLEY TSISLPLSLN
     DSIWDFKKNY FILKESQNIY FYNDIQNSIE LIFTNKDQSS LSPNFVLFKK NHWQLNNEKI
     VLIDNSNDLK TSLKELNLLD KKFTTIKKLK NFPNLNWHNL ILSNSTPNNL ALFNANLNKL
     LILDHNYNEL SQLNLNKLPN DIIWLNHNTI ICSFINDDGG DNDLIKLYSI DNNNSNSINF
     YLNSNILAWH LEVDGLKIFT SNSIEFLSLV QNYTSNCFKI GSIEHSAILL DSLNILNTNA
     PKAIENLKII NLNLAILDCI NSAKDEFDPF LQKKLLNAAS FGKSSLSIKN FDSNLFIKAC
     DIIKLLNQLN NLGIILTYNQ FNSIGLENCI KKLIQRNKYY ESFLIIKDLN FNSNFLNLNL
     EKFNHLINLI FKNWSINKIK NSKDLNDDEI FKILNQRLLI IEKNYFKDSN LSSLSMIEIA
     HAAYLEGRFN LTRNLSLLEK RPEYKIMELL ELNDHQLALK ESLITQSPQL ILSLLLKLSK
     ILSNVQLIKL IMLNISNENI YQYYNKENHE YLFDFYRQID SFKDLSILIF IDSKKKDQLN
     VFLSQIKDLY SNSIDKKKYF INDLIKQENL FEYQTNLSSK LNFNFVNLTI NETLKKLIEL
     NQNNEINEFI RKFKINEKKF LHLKIQKLIE LKNFNQLYQF ITSFKKPPIN YLIVYNYIKR
     SGNKLEASKY IKLMGANNGN NNNGKPISYD QMKQMYLDCK NYEELIYLCL KQKDIIGLKD
     LYKIIPPNQV EIRKLAHDTM ALM
//