ID I2GXE5_TETBL Unreviewed; 340 AA.
AC I2GXE5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Chromosome segregation in meiosis protein {ECO:0000256|RuleBase:RU366049};
GN Name=TBLA0A10180 {ECO:0000313|EMBL:CCH58797.1};
GN ORFNames=TBLA_0A10180 {ECO:0000313|EMBL:CCH58797.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH58797.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH58797.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- FUNCTION: Plays an important role in the control of DNA replication and
CC the maintenance of replication fork stability.
CC {ECO:0000256|RuleBase:RU366049}.
CC -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC TOF1 and CSM3. {ECO:0000256|ARBA:ARBA00011217}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU366049}.
CC -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000256|ARBA:ARBA00006075,
CC ECO:0000256|RuleBase:RU366049}.
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DR EMBL; HE806316; CCH58797.1; -; Genomic_DNA.
DR RefSeq; XP_004178316.1; XM_004178268.1.
DR AlphaFoldDB; I2GXE5; -.
DR STRING; 1071380.I2GXE5; -.
DR GeneID; 14492694; -.
DR KEGG; tbl:TBLA_0A10180; -.
DR eggNOG; KOG3004; Eukaryota.
DR HOGENOM; CLU_068300_0_0_1; -.
DR InParanoid; I2GXE5; -.
DR OrthoDB; 1388129at2759; -.
DR Proteomes; UP000002866; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; IEA:UniProtKB-UniRule.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0008156; P:negative regulation of DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0031297; P:replication fork processing; IEA:UniProtKB-UniRule.
DR InterPro; IPR012923; Csm3.
DR InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR PANTHER; PTHR13220; TIMELESS INTERACTING-RELATED; 1.
DR PANTHER; PTHR13220:SF11; TIMELESS-INTERACTING PROTEIN; 1.
DR Pfam; PF07962; Swi3; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU366049};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU366049};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication inhibitor {ECO:0000256|ARBA:ARBA00022880};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366049};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866}.
FT DOMAIN 57..137
FT /note="Chromosome segregation in meiosis protein 3"
FT /evidence="ECO:0000259|Pfam:PF07962"
FT REGION 185..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..340
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 340 AA; 38870 MW; D238245D71BA8CB1 CRC64;
MDTDESRFLE DFNINNNADA IDADTVNDID VDPTSVVDPI ISDPAAVVTR TRVPQIKLTS
ERLLCQKGLP FIMKNAPKRI RISKRKSNYD NLSNIVQFYQ LWAHELFPKA RFKDFIKLTH
DLGKTDRQLR EYRLDLLCSQ LGLPTSKEMY QENNSNDNII PEETNNESDL NQTLKFQNAE
HTTSINTNPV LSYNLNTNQS SPIINQTPST TNSEEQEDEL YIISKTNKST YAQQNSSSTS
FNTDDKNREN QNQQRGSVSG TPARIQIVNN AELNLPNSKG LSATKKASFS ELEDLEKELL
FESNSKLSLN NEADVLEQQQ YNDNYEDDED AMREMEQFDM
//
