ID   I2GYI7_TETBL            Unreviewed;       259 AA.
AC   I2GYI7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109};
DE            EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109};
DE   AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing] {ECO:0000256|ARBA:ARBA00032649};
DE   AltName: Full=Uroporphyrinogen-III cosynthase {ECO:0000256|ARBA:ARBA00031702};
GN   Name=TBLA0B03480 {ECO:0000313|EMBL:CCH59189.1};
GN   ORFNames=TBLA_0B03480 {ECO:0000313|EMBL:CCH59189.1};
OS   Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS   10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX   NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH59189.1, ECO:0000313|Proteomes:UP000002866};
RN   [1] {ECO:0000313|EMBL:CCH59189.1, ECO:0000313|Proteomes:UP000002866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC   UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004772}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000256|ARBA:ARBA00008133}.
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DR   EMBL; HE806317; CCH59189.1; -; Genomic_DNA.
DR   RefSeq; XP_004178708.1; XM_004178660.1.
DR   AlphaFoldDB; I2GYI7; -.
DR   STRING; 1071380.I2GYI7; -.
DR   GeneID; 14494735; -.
DR   KEGG; tbl:TBLA_0B03480; -.
DR   eggNOG; KOG4132; Eukaryota.
DR   HOGENOM; CLU_051874_0_1_1; -.
DR   InParanoid; I2GYI7; -.
DR   OMA; CDSMLRG; -.
DR   OrthoDB; 1472480at2759; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000002866; Chromosome 2.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR12390; UROPORPHYRINOGEN III SYNTHASE; 1.
DR   PANTHER; PTHR12390:SF0; UROPORPHYRINOGEN-III SYNTHASE; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002866}.
FT   DOMAIN          23..253
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
SQ   SEQUENCE   259 AA;  29606 MW;  D722B20371E261E6 CRC64;
     MNGNVILLKN PRESNSKDDD YYKIFDKYGY YPNFLPVITH TNIINQIVPV LNDSDYLDEL
     PFIIVTSQRA LTFLNEKDLN NQYPSQNFEK LLNKPVYTVG PATAKCLRNL KFKDIRGTET
     GNAEALAKLI ISELDQYDLT QKPLFLTGEK HKDTITKALK TKFNISVEEI VTYKTISLDD
     SLLRFKSVFK PNSWIILFSP QGTKDILKYL NDHKLNSSPF HLAAIGPYTR EYLISNDLKP
     DVVSPHPDPI SLVNSILTF
//