ID I2GYW4_TETBL Unreviewed; 559 AA.
AC I2GYW4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Purine-cytosine permease {ECO:0008006|Google:ProtNLM};
GN Name=TBLA0B04820 {ECO:0000313|EMBL:CCH59316.1};
GN ORFNames=TBLA_0B04820 {ECO:0000313|EMBL:CCH59316.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH59316.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH59316.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000256|ARBA:ARBA00008974}.
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DR EMBL; HE806317; CCH59316.1; -; Genomic_DNA.
DR RefSeq; XP_004178835.1; XM_004178787.1.
DR AlphaFoldDB; I2GYW4; -.
DR GeneID; 14494108; -.
DR KEGG; tbl:TBLA_0B04820; -.
DR eggNOG; ENOG502QQ8Y; Eukaryota.
DR HOGENOM; CLU_026016_2_2_1; -.
DR InParanoid; I2GYW4; -.
DR OMA; TIACVGW; -.
DR OrthoDB; 65220at2759; -.
DR Proteomes; UP000002866; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd11484; SLC-NCS1sbd_CobB-like; 1.
DR Gene3D; 1.10.4160.10; Hydantoin permease; 1.
DR InterPro; IPR001248; Pur-cyt_permease.
DR InterPro; IPR026030; Pur-cyt_permease_Fcy2/21/22.
DR PANTHER; PTHR31806; PURINE-CYTOSINE PERMEASE FCY2-RELATED; 1.
DR PANTHER; PTHR31806:SF1; PURINE-CYTOSINE PERMEASE FCY2-RELATED; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
DR PIRSF; PIRSF002744; Pur-cyt_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 120..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 61433 MW; 0084452A164476FB CRC64;
MEYYSSDTNS PSQGKDGTRI IMGHNSYDDP DSSNSRSSTD SKKNISTEKH VIDLEEKFQG
DTIYQLSSRN SFHDESSYSP KPGKIERFFK SLNAETNGIE PIPDEQKTDN SLLNAASMWF
SANLVLASYS LGVLGTAVYG LNFGQSAMVI IFFNIIGLLP VAFFSVFGAQ LSMRQMILSR
FLIGNVTARI FSIFNTIACG GWVVVNTIAA AQLLNMVNIG SGHNAPLWAG CLIVIGGTLL
VSFFGYGFIH TYEKYSWIPN FAIFLVIIAR LKMSGQYEEG PWTGGRTTAG NVLSFGSTVF
GFAAGWTTYA ADYTVYMPKS TNKCKIFFAL VAGLSFPLFF TQLIGAAAGT GVIKNAQWAK
LYDKNGTGGL TYGIIVQDSL HGFGQFCCVL LAMSTVAINI PGIYTLSMSV PAIWSKLNKV
PRIFWTFASN AVILGIAIPA CYYFTSFMQN FMDSISYFLA IYIAMSLSEH FIYRKGKFEN
YNIEDWNNPK NLPIGYAGVS GLIVGAFGVA IGMVQTYWRG EIGRLIGKDG GDIGFELGLS
WSFIAYNLIR PLELKYFGR
//
