ID I2H1K6_TETBL Unreviewed; 557 AA.
AC I2H1K6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Purine-cytosine permease {ECO:0008006|Google:ProtNLM};
GN Name=TBLA0C04620 {ECO:0000313|EMBL:CCH60258.1};
GN ORFNames=TBLA_0C04620 {ECO:0000313|EMBL:CCH60258.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH60258.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH60258.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000256|ARBA:ARBA00008974}.
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DR EMBL; HE806318; CCH60258.1; -; Genomic_DNA.
DR RefSeq; XP_004179777.1; XM_004179729.1.
DR AlphaFoldDB; I2H1K6; -.
DR GeneID; 14495238; -.
DR KEGG; tbl:TBLA_0C04620; -.
DR eggNOG; ENOG502QQ8Y; Eukaryota.
DR HOGENOM; CLU_026016_2_1_1; -.
DR InParanoid; I2H1K6; -.
DR OMA; GRWANYE; -.
DR OrthoDB; 65220at2759; -.
DR Proteomes; UP000002866; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd11484; SLC-NCS1sbd_CobB-like; 1.
DR Gene3D; 1.10.4160.10; Hydantoin permease; 1.
DR InterPro; IPR001248; Pur-cyt_permease.
DR InterPro; IPR026030; Pur-cyt_permease_Fcy2/21/22.
DR PANTHER; PTHR31806; PURINE-CYTOSINE PERMEASE FCY2-RELATED; 1.
DR PANTHER; PTHR31806:SF1; PURINE-CYTOSINE PERMEASE FCY2-RELATED; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
DR PIRSF; PIRSF002744; Pur-cyt_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 118..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 557 AA; 61485 MW; 280E760B1993AD5C CRC64;
MYSSESSSQS PQLKDETKVT LEYQLDEYDE YSNNLHQRDI KKINSMNKNS IDIESATNDD
IESYLSKQSG EAAVFEDTKI NWFTKFAASL DAEGNGIEPI PDEQKTDSSL INAASMWFSA
NMVLPSYSLG ILGTAVYGLN FGQAAMVIIF FNIMGLLSVA YFSIFGAQLS MRQMILSRFL
IGNVTARIYS IINTIACGGW GIVNTVAAAQ LLNMVNIGSG HNAPLWAGCL IIVGATVMVS
FFGYRVIHVY EKYSWIPNFA VFLVIIARLK KSGQYEEGPW TGGRTTAGNV LTFGCTVYGF
AAGWTTYAAD YTVYMPKSTN KYKIFFSLVA GLAFPLFFTQ LIGAASGTGV IKNTDWADLY
NKNGTGGLTY AILVKDSLHG FGQFCCVLLA MSTVSNNIPN MYTISMSVPA IWSKLNKIPR
VIWTLAANAV VLGISIPACY YFTEFMQYFM DSIGYYLSIY VAMSLSEHFI YRKGRFESYV
VEDWNNPKKL PIGYAGTAGL IVGAFGVALG MVQGYWKGEI GRLIGENGGD IGFELGLSWS
FIIYNIIRPF ELKYCGR
//
