ID I2H1Q4_TETBL Unreviewed; 640 AA.
AC I2H1Q4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN Name=TBLA0C05100 {ECO:0000313|EMBL:CCH60306.1};
GN ORFNames=TBLA_0C05100 {ECO:0000313|EMBL:CCH60306.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH60306.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH60306.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107}.
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DR EMBL; HE806318; CCH60306.1; -; Genomic_DNA.
DR RefSeq; XP_004179825.1; XM_004179777.1.
DR AlphaFoldDB; I2H1Q4; -.
DR STRING; 1071380.I2H1Q4; -.
DR GeneID; 14495286; -.
DR KEGG; tbl:TBLA_0C05100; -.
DR eggNOG; KOG2747; Eukaryota.
DR HOGENOM; CLU_014892_0_1_1; -.
DR InParanoid; I2H1Q4; -.
DR OrthoDB; 118560at2759; -.
DR Proteomes; UP000002866; Chromosome 3.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR040706; Zf-MYST.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF217; HISTONE ACETYLTRANSFERASE SAS3; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR Pfam; PF17772; zf-MYST; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 215..502
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT REGION 27..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 392
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 640 AA; 73665 MW; 038B3C5DE4B7F2C4 CRC64;
MTPLPRFLRN LQIDDNVHSG IAAAVLRDPD ARPAKRPRHV TATPQPSKSP DVLVPQQLPE
HVHSLNPELA DTPSAENAGD SRYNTWRLPQ SRAEADALSD YVLFPRTIAR SHSLGKDYNP
NVVGLKYDPH VFFNFHRLAR VRPKQREIEE RQRLSDKSRD AKHHVTHHVP RTIPSRADRR
RFRRLLTDSL PASNVNTNVP LTNIDNPITN ISEFTSSDGI QYVYLDDREI KTWFRSPFPP
HLNRNKLLFV CQHCLRYTGS RYAHTRHRVK CPVTFPPGNE VYRDGILSIW EVDGREQVRY
CRALCLLARL FLHSKTLYYD VEPFIFYVLT ERAADGKCRL VGYFSQEKLS AADYNLSCIL
VLPTYQRRGY GHFLIDFSYL LSRRSFKWGT PEKPLSDLGL LSYRSFWTLK VCQTLQMLKP
LAERADDGDD FNITLELLAN LTGMLPVDIV FGLEQLQLLY HKPTSHKYSI RINDWQIIDS
IVDRWNAKGY ATLDPTKLLW KPMIFGPSCG VNAVGTIETS SVSTPANPNI FVNKPTSPDP
FKKSIEMLVN FMQDDLADPR TMERSTLDTL INNPIITTSE FYHPGEWKLC FIQPQLNHKD
LQLSRKRYKS KRQLIDEEDG LLHTDDDTSS LTDVNIDSNI
//
