ID I2H322_TETBL Unreviewed; 582 AA.
AC I2H322;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=tRNA (uracil-O(2)-)-methyltransferase {ECO:0000256|ARBA:ARBA00017788, ECO:0000256|RuleBase:RU368004};
DE EC=2.1.1.211 {ECO:0000256|ARBA:ARBA00012795, ECO:0000256|RuleBase:RU368004};
GN Name=TBLA0D02710 {ECO:0000313|EMBL:CCH60774.1};
GN ORFNames=TBLA_0D02710 {ECO:0000313|EMBL:CCH60774.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH60774.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH60774.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- FUNCTION: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-
CC methyltransferase. {ECO:0000256|RuleBase:RU368004}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-
CC methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:43100, Rhea:RHEA-COMP:10339, Rhea:RHEA-COMP:10340,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:65315, ChEBI:CHEBI:74478; EC=2.1.1.211;
CC Evidence={ECO:0000256|ARBA:ARBA00000660,
CC ECO:0000256|RuleBase:RU368004};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU368004}.
CC -!- SIMILARITY: Belongs to the TRM44 family.
CC {ECO:0000256|ARBA:ARBA00009056, ECO:0000256|RuleBase:RU368004}.
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DR EMBL; HE806319; CCH60774.1; -; Genomic_DNA.
DR RefSeq; XP_004180293.1; XM_004180245.1.
DR AlphaFoldDB; I2H322; -.
DR STRING; 1071380.I2H322; -.
DR GeneID; 14495810; -.
DR KEGG; tbl:TBLA_0D02710; -.
DR eggNOG; KOG3790; Eukaryota.
DR HOGENOM; CLU_018580_2_0_1; -.
DR InParanoid; I2H322; -.
DR OMA; IREPNIN; -.
DR OrthoDB; 1353816at2759; -.
DR Proteomes; UP000002866; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0141101; F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030488; P:tRNA methylation; IEA:UniProtKB-UniRule.
DR InterPro; IPR011671; tRNA_uracil_MeTrfase.
DR PANTHER; PTHR21210:SF0; TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR21210; UNCHARACTERIZED; 1.
DR Pfam; PF07757; AdoMet_MTase; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU368004};
KW Methyltransferase {ECO:0000256|RuleBase:RU368004};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866};
KW S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU368004};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU368004};
KW tRNA processing {ECO:0000256|RuleBase:RU368004}.
FT REGION 482..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 66121 MW; 29ED7869D5A0043F CRC64;
MAKTSSKQNE NFHFNASNVS SNILGSSWVN LYSTIEKVTF SKEDFQNAML NVIREPNINS
TVVLRADILN EITYSPSDGE EIEHITQDLD KLPIPDKDAV QINLNDITPR VDLFNDSDEK
NFEKKHDIFI WKQIVRRVIP RNVFKDAIIN QTCLLLNSKN PTFKETSLVI YTPHLNNPDD
CPFYLPKVKS VGILLHESIL SVHYLPFSDE TVTKENSIPP VLLDENDRMV RTAYRLLQTA
NKHSNGVMQG YEKRVTHDQI ISKVVFQNRY VQLKKKYSKF LVDSWVESTD PKKHVFEDIS
IAAFLIELWI KIYGTNFREK MQFRDLGCGN GVLVYILISE GVNGVGTDAR RRKSWSIYPS
NVQASLTEQV IVPALLLRPY PTLHQMYPNI DYNSNVFPVK LGNSEESTPD VPQKAILYSS
KDLLDSPRVC TTEFPPNTFI IGNHSDELTC WIPLLGYPFM VIPCCSHGFS GQRVRYRVKK
NKSDIQKTPS PANQNNNNKG NSSYAGLVSE VEDISNKVGW QARLELLRIP STRNAAIVAY
ENKNALASFP TQEVYEVIQN GGGAGGWIEN TMNLMKKKPR GH
//