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Database: UniProt
Entry: I2H340_TETBL
LinkDB: I2H340_TETBL
Original site: I2H340_TETBL 
ID   I2H340_TETBL            Unreviewed;       258 AA.
AC   I2H340;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=Proteasome alpha-type subunits domain-containing protein {ECO:0000259|PROSITE:PS00388};
GN   Name=TBLA0D02920 {ECO:0000313|EMBL:CCH60792.1};
GN   ORFNames=TBLA_0D02920 {ECO:0000313|EMBL:CCH60792.1};
OS   Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS   10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX   NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH60792.1, ECO:0000313|Proteomes:UP000002866};
RN   [1] {ECO:0000313|EMBL:CCH60792.1, ECO:0000313|Proteomes:UP000002866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC   UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- FUNCTION: The proteasome degrades poly-ubiquitinated proteins in the
CC       cytoplasm and in the nucleus. It is essential for the regulated
CC       turnover of proteins and for the removal of misfolded proteins. The
CC       proteasome is a multicatalytic proteinase complex that is characterized
CC       by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu
CC       adjacent to the leaving group at neutral or slightly basic pH. It has
CC       an ATP-dependent proteolytic activity. {ECO:0000256|ARBA:ARBA00003542}.
CC   -!- SIMILARITY: Belongs to the peptidase T1A family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00808}.
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DR   EMBL; HE806319; CCH60792.1; -; Genomic_DNA.
DR   RefSeq; XP_004180311.1; XM_004180263.1.
DR   AlphaFoldDB; I2H340; -.
DR   STRING; 1071380.I2H340; -.
DR   GeneID; 14495828; -.
DR   KEGG; tbl:TBLA_0D02920; -.
DR   eggNOG; KOG0178; Eukaryota.
DR   HOGENOM; CLU_035750_4_3_1; -.
DR   InParanoid; I2H340; -.
DR   OMA; YVLNDNM; -.
DR   OrthoDB; 166567at2759; -.
DR   Proteomes; UP000002866; Chromosome 4.
DR   GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IEA:UniProt.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:UniProt.
DR   Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR023332; Proteasome_alpha-type.
DR   InterPro; IPR000426; Proteasome_asu_N.
DR   InterPro; IPR001353; Proteasome_sua/b.
DR   PANTHER; PTHR11599:SF13; PROTEASOME SUBUNIT ALPHA TYPE-4; 1.
DR   PANTHER; PTHR11599; PROTEASOME SUBUNIT ALPHA/BETA; 1.
DR   Pfam; PF00227; Proteasome; 1.
DR   Pfam; PF10584; Proteasome_A_N; 1.
DR   SMART; SM00948; Proteasome_A_N; 1.
DR   SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR   PROSITE; PS00388; PROTEASOME_ALPHA_1; 1.
DR   PROSITE; PS51475; PROTEASOME_ALPHA_2; 1.
PE   3: Inferred from homology;
KW   Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PROSITE-
KW   ProRule:PRU00808}; Reference proteome {ECO:0000313|Proteomes:UP000002866}.
FT   DOMAIN          6..28
FT                   /note="Proteasome alpha-type subunits"
FT                   /evidence="ECO:0000259|PROSITE:PS00388"
SQ   SEQUENCE   258 AA;  28998 MW;  F9F0AD43CBA1C9D4 CRC64;
     MGSRRYDSRT TIFSPEGRLY QVEYALESIS HAGTSIGIMS KDGIVLLAER KITSKLLEQD
     ILNEKLYKLS DKITLAVAGL TADAEILINI ARQFAQNYLM TYNEEIPVEI LVKKLSDIKQ
     SYTQHGGLRP FGVSFIYAGY DDILGPQLYT SNPSGNYTGW KAISIGANTS AAQTLLQMDY
     KDDMNLNDAM ELGLKTLSKT TDSSNLTYDR VELSIIKIDK ENDNKIIQKI YNPAEIKQLL
     IKFGINKKND EDEDVEMK
//
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