ID I2H439_TETBL Unreviewed; 691 AA.
AC I2H439;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=DNA polymerase epsilon subunit B {ECO:0000256|ARBA:ARBA00016011};
DE AltName: Full=DNA polymerase II subunit 2 {ECO:0000256|ARBA:ARBA00032930};
GN Name=TBLA0E00800 {ECO:0000313|EMBL:CCH61141.1};
GN ORFNames=TBLA_0E00800 {ECO:0000313|EMBL:CCH61141.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH61141.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH61141.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC {ECO:0000256|ARBA:ARBA00009560}.
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DR EMBL; HE806320; CCH61141.1; -; Genomic_DNA.
DR RefSeq; XP_004180660.1; XM_004180612.1.
DR AlphaFoldDB; I2H439; -.
DR STRING; 1071380.I2H439; -.
DR GeneID; 14496267; -.
DR KEGG; tbl:TBLA_0E00800; -.
DR eggNOG; KOG3818; Eukaryota.
DR HOGENOM; CLU_010628_1_0_1; -.
DR InParanoid; I2H439; -.
DR OMA; PEDGAWF; -.
DR OrthoDB; 166885at2759; -.
DR Proteomes; UP000002866; Chromosome 5.
DR GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR016266; POLE2.
DR PANTHER; PTHR12708:SF0; DNA POLYMERASE EPSILON SUBUNIT 2; 1.
DR PANTHER; PTHR12708; DNA POLYMERASE EPSILON SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866}.
FT DOMAIN 410..652
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 116..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 79537 MW; F093DAD3E2CDAED0 CRC64;
MFNSSTVLPA KVPPNLVRPL AYRILSKKHG LNIKSNGLNE LSKNIGIYFG MDWKRNPKMF
EFLEIFAQVW KEQERGLFVD DVGVKGVITE MKEREKVELN RLDVQKNSRQ KNVLNMLDLG
PRGNDMDIDQ DDNEMPLQNT SLPSLPIDMD SQDTINITQE PQESQESREP IQSLEDQATE
LDWQDYFKLI GAWDQQKFTY DPIKSQFRYS QSQKKKILPN IEDKLNLFKT RYNLTKDRVL
RNEDFQNVDT FNPLSSIVAM NNELNQQSTN AIDNNVSITP IKNLIGQDGR NFLIMGMIYK
SPRGRWCMED ASGSIEINIS QTIPTDGTYY VPGCIVIAEG IYFSAGDTFH VTSMTQPPGE
KRLNTLEAIG NLDLLGVHGQ SNVNYISRLD NELKIRLHYL ERELTDNIFV ILGGDLFLDE
LKTFDALKKI FEKLNEDPPI VLILLGSFSQ KPIFATMNNH RISSSEQYKN NFDTLATLLT
QFENLIATTT FIFIPGVNDP WGSSVSLGSS TTLPQRNIPE EYQSKINRIC KKTYWGTNPM
RLAYLSQEII IMRDDLRDRF KRHNIEFPIV VEKQIKEQEL SIDKSDDDIP IDKLPSHLKE
SRKIVKTLLD QGHLSPFLMN IRPIVWDLDF CLNMYPIPSL LILSDSSCDK FDVTYNGCKV
INSGTFINNR RARYIEYSPS LRRSIEQEIN F
//
